Love the figures!! Great work 😄

In conclusion, neuronal activity surrounding micro-arousals is complex and under strong homeostatic regulation. We still have a lot to learn about this mysterious feature of sleep!
Thanks to @vyazovskiy.bsky.social lab and co-authors for letting me play around with the amazing data 📊

5) Short (duration below 3 seconds) arousals tend to be associated with an overall decrease in firing rate, but not longer lasting arousals

4) Analysis of single channels within the cortical layers showed that some channels exhibit increased firing rates right before the micro-arousal while other channels have decreased firing during the micro-arousal

3) NREM sleep micro-arousals have different neuronal activity profiles than micro-arousals following REM sleep

2) slow wave activity (SWA) in a ~10s period immediately after micro-arousals is highly sensitive to sleep/wake history to an extent where post-arousal SWA is higher than NREM sleep SWA in sleep deprived mice

1) micro-arousals are associated with a decrease in power throughout the layers of the motor cortex

Awesome paper, really enjoyed reading it! Would be interesting to know if those C1 waves coincide with noradrenaline release 🤔

If any of you have questions or comments or want do discuss the findings, please write! 😀 Let's have a journal club 😎

Furthermore, we find that the sleep aid Zolpidem (Ambien) disrupt the pumping system and impairs brain cleaning 🧠🚿