Mikki McGuinty
@mykkymcg.bsky.social
Ottawa, Canada.
ID Physician and Clinician Scientist. HIV, particularly in women and pregnancy, TB, and maternal & maternal/fetal infections and immunity
ID Physician and Clinician Scientist. HIV, particularly in women and pregnancy, TB, and maternal & maternal/fetal infections and immunity
Didn’t we… already know this?
May 8, 2025 at 12:49 AM
Didn’t we… already know this?
I’m so confused about what infection they thought HEPA filters would prevent.
April 14, 2025 at 1:23 AM
I’m so confused about what infection they thought HEPA filters would prevent.
I kind of agree I would like to see that oral Tx alone for the partner doesn’t suffice, it seems like it should logically follow that simultaneous treatment topically for women would help… but that ignores the reality that oral drugs are delivered to the mucosa quite well.
March 10, 2025 at 6:02 PM
I kind of agree I would like to see that oral Tx alone for the partner doesn’t suffice, it seems like it should logically follow that simultaneous treatment topically for women would help… but that ignores the reality that oral drugs are delivered to the mucosa quite well.
Epiglottis seems impossible not to be a problem, but also so wildly uncommon that I’m surprised to see it get its own line on such a table.
January 16, 2025 at 1:34 AM
Epiglottis seems impossible not to be a problem, but also so wildly uncommon that I’m surprised to see it get its own line on such a table.
There were events in all the clinical trials, which only had about 20000 participants altogether, so this is not unexpected.
January 8, 2025 at 1:05 AM
There were events in all the clinical trials, which only had about 20000 participants altogether, so this is not unexpected.
But they’re so good though.
December 24, 2024 at 12:21 AM
But they’re so good though.
This feels too complicated to be helpful.
December 20, 2024 at 3:19 AM
This feels too complicated to be helpful.
Someone spoil it for me.
December 20, 2024 at 3:09 AM
Someone spoil it for me.
Ie… if you let as many exposure events accumulate in both studies would the girls end up with a couple infections too.
Girls metabolize injectable Cabitegravir differently than boys, could this also be true for Len?
Too many differences to compare!
Girls metabolize injectable Cabitegravir differently than boys, could this also be true for Len?
Too many differences to compare!
December 17, 2024 at 2:44 AM
Ie… if you let as many exposure events accumulate in both studies would the girls end up with a couple infections too.
Girls metabolize injectable Cabitegravir differently than boys, could this also be true for Len?
Too many differences to compare!
Girls metabolize injectable Cabitegravir differently than boys, could this also be true for Len?
Too many differences to compare!
One group also has vaginas. The other has fewer.
Not sure they quantified the frequency of sexual activity and average number of new partners, but would be important to know if you want to compare the intervention between these groups.
The boys also seemed better about taking oral PrEP.
Not sure they quantified the frequency of sexual activity and average number of new partners, but would be important to know if you want to compare the intervention between these groups.
The boys also seemed better about taking oral PrEP.
December 17, 2024 at 2:43 AM
One group also has vaginas. The other has fewer.
Not sure they quantified the frequency of sexual activity and average number of new partners, but would be important to know if you want to compare the intervention between these groups.
The boys also seemed better about taking oral PrEP.
Not sure they quantified the frequency of sexual activity and average number of new partners, but would be important to know if you want to compare the intervention between these groups.
The boys also seemed better about taking oral PrEP.
A population-specific difference in risk/time is also at play in comparison.
December 16, 2024 at 3:10 AM
A population-specific difference in risk/time is also at play in comparison.
2 infections is still an incredibly low number even in a PrEP trial, we’re only looking askance at it because PURPOSE-1 got to put up a “zero” here. But we knew it wasn’t going to be zero everywhere.
December 16, 2024 at 2:14 AM
2 infections is still an incredibly low number even in a PrEP trial, we’re only looking askance at it because PURPOSE-1 got to put up a “zero” here. But we knew it wasn’t going to be zero everywhere.
AKA… just don’t. You don’t need this test. And you don’t need to wait for any positive test to treat what is most likely TB. If you diagnose something else you can always stop treating (or not).
December 15, 2024 at 3:33 AM
AKA… just don’t. You don’t need this test. And you don’t need to wait for any positive test to treat what is most likely TB. If you diagnose something else you can always stop treating (or not).
Depends on how good the source control is. If it’s perfect, 5 days. Usually the wound looks like a hot mess at day 5. So then I treat until it isn’t.
November 26, 2024 at 1:09 AM
Depends on how good the source control is. If it’s perfect, 5 days. Usually the wound looks like a hot mess at day 5. So then I treat until it isn’t.
Interesting!
Will have to try it alongside the one routinely used now that does:
www.tstin3d.com/en/calc.html
Will have to try it alongside the one routinely used now that does:
www.tstin3d.com/en/calc.html
The Online TST/IGRA Interpreter
www.tstin3d.com
November 21, 2024 at 11:45 AM
Interesting!
Will have to try it alongside the one routinely used now that does:
www.tstin3d.com/en/calc.html
Will have to try it alongside the one routinely used now that does:
www.tstin3d.com/en/calc.html
I think the whole country probably has 10-20? At least the last time I asked!
November 16, 2024 at 12:14 PM
I think the whole country probably has 10-20? At least the last time I asked!