Zhongyue (John) Yang
@mutexazjy.bsky.social
AP of Chemistry @Vanderbilt. Emphasize physics-guided protein engineering.
Things tend to slow down in winter, but Elsa Ding and Yaoyukun Jiang from our group have engineered a 'cold-adapted' version of a mesophilic amylase. Even with a 45-degree temperature drop, we still observe 30% activity. onlinelibrary.wiley.com/doi/10.1002/... @angewandtechemie.bsky.social
Enhancing Cold Adaptation of Bidomain Amylases by High‐Throughput Computational Engineering
This work uncovers molecular determinants of cold adaptation in bidomain amylases by combining MD simulations and biochemical assays, revealing that increased domain separation drives enhanced activi...
onlinelibrary.wiley.com
May 12, 2025 at 6:55 AM
Things tend to slow down in winter, but Elsa Ding and Yaoyukun Jiang from our group have engineered a 'cold-adapted' version of a mesophilic amylase. Even with a 45-degree temperature drop, we still observe 30% activity. onlinelibrary.wiley.com/doi/10.1002/... @angewandtechemie.bsky.social
Physics-based modeling is key to unlocking the full potential of enzyme engineering!
📢A Perspective from Zhongyue J. Yang and colleagues highlights the role of physics-based modeling in computational enzyme engineering, noting key challenges and opportunities for integrating machine learning and their synergistic future. www.nature.com/articles/s43... #chemsky
Physics-based modeling in the new era of enzyme engineering - Nature Computational Science
This Perspective highlights the vital role of physics-based modeling in computational enzyme engineering, exploring key advances, challenges and future steps. By integrating machine learning, these ap...
www.nature.com
April 29, 2025 at 6:46 AM
Physics-based modeling is key to unlocking the full potential of enzyme engineering!