Ben Munro
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munromit.bsky.social
Ben Munro
@munromit.bsky.social
150 followers 130 following 8 posts
Postdoc in the Larsson lab, Karolinska Institutet. Interested in #mitochondria, particularly #mtDNA, in health and disease. 🧬
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Reposted by Ben Munro
wredenberglab.bsky.social
Excited to share our latest work on how mitochondrial methylation shapes gene expression. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis.
Thanks to everyone invovled. @ruthicglasgow.bsky.social @amunts.bsky.social
🔗 rdcu.be/etk12
The mitochondrial methylation potential gates mitoribosome assembly
Nature Communications - Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation,...
rdcu.be
June 25, 2025 at 2:16 PM
munromit.bsky.social
We're looking for a postdoc! 🧑‍🔬 If you're interested in mitochondrial genetics, have a look below! 🧬🔬🥼
Feel free to ask any questions.

ki.varbi.com/what:job/job...
Postdoctoral studies in mitochondrial genetics (scholarship)
Postdoctoral studies in mitochondrial genetics (scholarship) Do you want to contribute to improving human health? Join a leading research team dedicated to understanding how mutations of mitochondrial
ki.varbi.com
April 25, 2025 at 2:50 PM
munromit.bsky.social
🧬 New paper! We nudge the science forward surrounding deoxynucleoside supplementation & mitochondrial DNA depletion syndromes (MDDS).⁣
We show, for the first time in vivo, that deoxynucleoside supplementation can mitigate effects of RRM2B mutations.
🔗 academic.oup.com/hmg/advance-...
Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome
Abstract. Mitochondrial DNA (mtDNA) depletion syndromes (MDDS) are rare, clinically heterogeneous mitochondrial disorders resulting from nuclear variants i
academic.oup.com
April 11, 2025 at 10:03 PM
Reposted by Ben Munro
mito-at-gu.bsky.social
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration.
www.nature.com/articles/s41...
Small molecules restore mutant mitochondrial DNA polymerase activity - Nature
An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.
www.nature.com
April 9, 2025 at 4:30 PM
Reposted by Ben Munro
frisophagy.bsky.social
How many times have you read that mitochondria has fewer DNA repair mechanisms that the nucleus? When was last time you checked it out?

DNA repair pathways in the mitochondria

Dillon King and William Copeland
DNA repair pathways in the mitochondria
Mitochondria contain their own small, circular genome that is present in high copy number. The mitochondrial genome (mtDNA) encodes essential subunits…
www.sciencedirect.com
February 15, 2025 at 4:50 PM
munromit.bsky.social
Great to hear talks from this year's winners of the Nobel Prize in Physiology or Medicine, Gary Ruvkun and Victor Ambrose. Very inspiring! #nobelprize
The stage of the Erling Persson Hall auditorium in Alua Medica, Karolinska Institutet before the Nobel Lecture 2024 Gary Ruvkun, joint winner of the 2024 Nobel Prize in Physiology or Medicine, giving his Nobel Lecture.
December 7, 2024 at 5:58 PM