Mueller Lab (KCL)
@mueller-lab-kcl.bsky.social
Chemical Biology Lab - Interests in Protein Chemistry; Post-translational modifications, especially those that occur on the polypeptide backbone; p53 signalling; molecular ageing.
We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity in vitro. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.
February 3, 2025 at 10:15 PM
We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity in vitro. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.