Steve Alexander (he/him)
mqzspa.bsky.social
Steve Alexander (he/him)
@mqzspa.bsky.social
Science (pharmacology & biochemistry of cannabinoids & any other drug targets); music (eclectic); sport (rugby union, touch, cycling)
The Guinness does definitely slide down easy in Belfast
December 14, 2025 at 9:18 PM
The International Cannabinoid Research Society begins this evening in a great venue.
#ICRSBloomington #ICRS2025
July 6, 2025 at 5:44 PM
The Hunt for the Putative Epoxyeicosatrienoic Acid Receptor | ACS Chemical Biology pubs.acs.org/doi/full/10....
The Hunt for the Putative Epoxyeicosatrienoic Acid Receptor
Epoxyeicosatrienoic acids, or EETs, are signaling molecules formed by the metabolism of arachidonic acid by cytochrome P450 enzymes. They are well-known for their anti-inflammatory effects, their ability to lower blood pressure, and benefits to cardiovascular outcomes. Despite the wealth of data demonstrating their physiological benefits, the putative high-affinity receptor that mediates these effects is yet to be identified. The recent report that the sphingosine-1-phosphate receptor 1 (S1PR1) is a high-affinity receptor for a related epoxy lipid prompted us to ask, “Why has the putative EET receptor not been discovered yet? What information about the discoveries of lipid epoxide receptors can help us identify the putative EET receptor?” In this review, we summarize the evidence supporting that the putative EET receptor exists. We then review the data showing EETs binding to other, low-affinity receptors and the discovery of receptors for similar lipid metabolites that can serve as a model for identifying the putative EET receptor. We hope this review will revitalize the search for this important receptor, which can facilitate the development of anti-inflammatory and cardiovascular therapeutics.
pubs.acs.org
March 28, 2025 at 7:19 PM
"Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase | Nature"
www.nature.com/articles/s41...
Structure and mechanism of vitamin-K-dependent γ-glutamyl carboxylase - Nature
Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.
www.nature.com
February 11, 2025 at 11:36 AM
"Molecular basis of vitamin K driven γ-carboxylation at membrane interface | Nature"
www.nature.com/articles/s41...
Molecular basis of vitamin K driven γ-carboxylation at membrane interface - Nature
Nature - Molecular basis of vitamin K driven γ-carboxylation at membrane interface
www.nature.com
February 11, 2025 at 11:35 AM
"Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis: Cell Reports"
www.cell.com/cell-reports...
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease via the prosaposin-GPR37-IL-6 axis
Ma et al. identify that oligodendrocytes drive PD-like neurodegeneration via the prosaposin-GPR37-IL-6 axis. GPR37 is upregulated in oligodendrocytes, and prosaposin secretion is increased in parkinso...
www.cell.com
February 11, 2025 at 11:30 AM
Just after dawn of the start of a week in Harrogate (north Yawkshire) at the @britpharmsoc.bsky.social Annual Meeting
December 9, 2024 at 9:11 AM
"Puny human"
September 15, 2024 at 9:16 AM
Toy Story plot suggestion: one of the dolls attends Medical School. Scores well on social interaction, marginally on anatomy, fails pharmacology. Definitely has a future as a GP
September 6, 2024 at 10:49 AM
"Natural product pharmacology: the British Journal of Pharmacology perspective"
pubmed-ncbi-nlm-nih-gov.nottingham.idm.oclc.org/39128855/
Shibboleth Authentication Request
pubmed-ncbi-nlm-nih-gov.nottingham.idm.oclc.org
August 26, 2024 at 7:40 PM