UC Davis Mouse Biology Program
@mousebiology.bsky.social
A resource providing scientific expertise and consultation, technological assistance, and educational support to the research community in developing, applying, and using genetically altered mice for biomedical research on diseases and disorders.
The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio
November 18, 2025 at 7:27 PM
The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio
The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-
November 12, 2025 at 9:48 AM
The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-1st-
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
November 10, 2025 at 1:38 PM
Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY
James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
November 7, 2025 at 11:43 PM
James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
https://www.yahoo.com/news/articles/james-watson-co-discoverer-double-1957www.yahoo.com/n
As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:
November 7, 2025 at 6:24 PM
As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:
IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
October 30, 2025 at 10:04 PM
IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
‘Insights from the Past, Shaping the Future’
Program and key information
👉 https://www.mousephenotype.org/news/2025-virtual-impc-conference-registration-and-agenda/
Free Registration
👉https://tinyurl.com/yz7znkde
🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/
October 22, 2025 at 4:21 PM
🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: https://www.genengnews.com/topics/omics/eric-green-receives-ashg-leadership-award-to-standing-ovation/
"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."
https://EcKc5wILd4%3D
https://EcKc5wILd4%3D
October 20, 2025 at 8:17 PM
"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."
https://EcKc5wILd4%3D
https://EcKc5wILd4%3D
MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule
October 15, 2025 at 6:38 PM
MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule
What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699
October 13, 2025 at 1:18 PM
What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: https://www.statnews.com/2025/10/09/crispr-cure-baby-kj-rare-diseases-personalized-gene-editing-drugs/?_hsmi=38470699
Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH
October 6, 2025 at 5:28 PM
Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH
“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
October 3, 2025 at 6:18 PM
“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...
Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704
September 18, 2025 at 10:25 PM
🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
September 15, 2025 at 11:59 PM
🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge
In this latest episode, we reflect on the past year at the Mouse Biology Program — what we’ve achieved, the challenges we’ve tackled, and how our work is shaping the future of research.
September 2, 2025 at 10:11 PM
In this latest episode, we reflect on the past year at the Mouse Biology Program — what we’ve achieved, the challenges we’ve tackled, and how our work is shaping the future of research.
A great question...
https://www.theatlantic.com/health/archive/2025/08/nih-funding-whiplash/683773/?gift=4lmIFlDypD2qizi37OjlOFcAyBgKZPvOqwBmeZV_gRM&utm
https://www.theatlantic.com/health/archive/2025/08/nih-funding-whiplash/683773/?gift=4lmIFlDypD2qizi37OjlOFcAyBgKZPvOqwBmeZV_gRM&utm
August 6, 2025 at 9:52 PM
July 23, 2025 at 6:19 PM
"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.
July 17, 2025 at 7:01 PM
"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.
Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/
July 7, 2025 at 7:25 PM
Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/
What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...
June 13, 2025 at 7:03 PM
What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330
May 29, 2025 at 5:27 PM
Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330
Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! Source: www.nejm.org/doi/full/10....
May 20, 2025 at 9:05 PM
Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! Source: www.nejm.org/doi/full/10....
Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.
May 16, 2025 at 8:16 PM
Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.
Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...
May 14, 2025 at 7:04 PM
Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...
Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301
May 7, 2025 at 6:37 PM
Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301