Morkos Henen
@morkoshenen.bsky.social
Associate Professor - Research @University of Colorado, Denver. Ph.D. In Molecular Biology, Vienna University
We uncover the first evidence that the long-mysterious Zβ domain of #ADAR1 binds G-quads, a surprising twist that reshapes how we think about ADAR targeting—opening new directions for understanding the links between innate immunity and splicing regulation. #NMR #RNA
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Zα and Zβ domains of ADAR1 and ZBP1 bind to G-quadruplexes with low micromolar affinity
While it is well established that the Zα domains of ADAR1 and ZBP1 proteins bind Z-form prone nucleic acid, it has also been shown that the Zα domain of ADAR1 binds DNA G-quadruplexes. However, no bin...
www.biorxiv.org
November 20, 2025 at 5:33 PM
We uncover the first evidence that the long-mysterious Zβ domain of #ADAR1 binds G-quads, a surprising twist that reshapes how we think about ADAR targeting—opening new directions for understanding the links between innate immunity and splicing regulation. #NMR #RNA
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...