8/ 8/ The work now begins to understand the functional implications of peroxiredoxin heterooligomerisation and its implications for our current view of these fascinating proteins.

With Armindo Salvador, we determined that it is possible to form as many as 120 distinct heterodecameric complexes with two monomeric components.

6/ With @riemerlab.bsky.social we could also show the presence of PRDX1-PRDX2 heterooligomers in HEK293T cells.

5/ Heterooligomerisation is inducible in response to oxidative challenge in yeast and stabilises Tsa1 as a Tsa1-Tsa2 heterodecameric complex.

4/ With the Messens lab, we used negative stain EM to visualise heterooligomers and show that heterooligomerisation strongly affects dimer-decamer equilbrium.

3/ Long considered to only form homooligomeric complexes, we find that pairs of peroxiredoxins from human, yeast, plant and parasite readily assemble into heterodimers and heterodecamers.