computations
moonlanding.exposed
computations
@moonlanding.exposed
Bioinformatics Postdoc. Historical Biogeography and aDNA analysis. Developer of Lagrange-NG (https://github.com/computations/lagrange-ng) and bigrig (https://github.com/computations/bigrig)
In addition the above work, we also re-implemented the aDNA simulator gargammel (which implements the Briggs model of aDNA damage) in a easier to use python package called pygargammel:

github.com/computations...
GitHub - computations/pygargammel
Contribute to computations/pygargammel development by creating an account on GitHub.
github.com
June 17, 2025 at 7:30 AM
The main take away from the paper is that, of the sources of damage common to aDNA, the only one that really "matters" is fragment length. Other sources, such as single or double strand deamination, are not significant enough to strongly degrade placement accuracy.
June 17, 2025 at 7:23 AM