Mohit Dubey
@mohitdubey.bsky.social
Pharmacologist, Neurophysiologist, Dementia fellow. Studying neuro-glia in circuits. father of a kid. person profile.
Reposted by Mohit Dubey
Check out our new preprint! We combine EM data, genetically encoded tools and single-cell electrophysiology to investigate mitochondria at the AIS, where they cluster and strongly buffer Ca2+. Surprisingly, they don't impact electrophysiological properties.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation
Mitochondria are diverse and multifaceted intracellular organelles regulating oxidative energy supply, lipid metabolism and calcium (Ca2+) signaling. In neurons the spatial sequestration of cytoplasmi...
www.biorxiv.org
May 24, 2025 at 10:58 AM
Check out our new preprint! We combine EM data, genetically encoded tools and single-cell electrophysiology to investigate mitochondria at the AIS, where they cluster and strongly buffer Ca2+. Surprisingly, they don't impact electrophysiological properties.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...