21. 🐟 Warty oreo: 140 yrs
22.🐢 Eastern box turtle: 138 yrs
23. 🐢 Mediterranean spur-thighed tortoise: 127 yrs
24. 🧑 Human: 122.5 yrs
25. 🐢 European pond turtle: 120 yrs

Source: AnAge Database

14. 🌰 Red sea urchin: 200 yrs
15.🐢 Galapagos tortoise: 177 yrs
16.🐚 Pacific geoduck: 168 yrs
17.🐟 Shortraker rockfish: 157 yrs
18.🐟 Lake sturgeon: 152 yrs
19. 🐢 Aldabra tortoise: 152 yrs
20.🐟 Orange roughy: 149 yrs

6. 🌳 Umbrella thorn: 650 yrs
7. 🐚 Ocean quahog clam: 507 yrs
8. 🦈 Greenland shark: 392 yrs
9. 🪱 Escarpia laminata: 300 yrs
10. 🌵 Saguaro: 300 yrs
11. 🪱 Lamellibrachia luymesi: 250 yrs
12. 🐋 Bowhead whale: 211 yrs
13. 🐟 Rougheye rockfish: 205 yrs

Source: www.nature.com/articles/s43...

10/ This is quite significant because it decomplexes body temperature from basic metabolism or calorie restriction an often coupled mechanisms. These findings hint at a new therapeutic strategy to slow ageing and treat age-related diseases.

9/ When researchers separated the effects of reduced metabolism and calorie restriction from that of lower body temperature, only the drop in temperature significantly slowed epigenetic ageing. The bigger the drop, the slower the ageing process.

8/ More surprisingly, there was also an increase in DNA repair and antioxidant defences. Mice were not only molecularly younger, but they were physically healthier and functionally younger, as measured by the mouse frailty index.

7/ It is not only slowing down molecular ageing, but also increasing cellular resilience. Gene expression analyses showed the expected shift towards glucose metabolism and lipid synthesis typical of an animal in an energy conservation mode.

6/ Surprisingly, transcriptomic ageing clocks showed different results with significant slowing in the kidney and cortex as well, which were non-significant in the epigenetic ageing clocks. It also showed that there might be sex differences, with liver ageing being slower in females than in males.

5/ Different organs responded in different ways: blood epigenetic ageing slowed by about 80%, the liver by 20%. This means that the benefits of lower core temperature could be tissue specific.

4/ It’s long been observed that animals that hibernate tend to live longer than their non-hibernating relatives. Here, inducing torpor in mice slowed metabolism and lowered body temperature, which in turn slowed down their epigenetic ageing.

3/ New research from Nature Aging has shown how this works in practice. Researchers induced a hibernation-like state, or torpor, in mice that don't naturally hibernate by activating specific preoptic neurons using molecular techniques that could keep them hibernating for days and weeks.

2/ Lowering core body temperature was previously shown to slow cellular ageing by preventing protein aggregation and boosting protein quality control in cells. This is true for cold blooded animals as well as warm blooded animals, including mammals.

Resource: bbc.co.uk/news/articles/cjdn10yk0k1o