Madelynn Whittaker
@mnwhittaker.bsky.social
boston-based scientist editing DNA and occasionally her coffee order
And lastly, this work represents a substantial collaborative effort. A big congratulations to co-first author @laurenctesta.bsky.social and all co-authors involved in the project! 🥳
October 28, 2025 at 7:36 PM
And lastly, this work represents a substantial collaborative effort. A big congratulations to co-first author @laurenctesta.bsky.social and all co-authors involved in the project! 🥳
We hope these findings help advance the development of more precise and potent genome-editing therapies. 🙌🏼
October 28, 2025 at 7:36 PM
We hope these findings help advance the development of more precise and potent genome-editing therapies. 🙌🏼
Across multiple disease-relevant targets, we found that chimeric RNA:DNA hybrid guides can — both in vitro and in vivo —
1) Increase on-target corrective editing
2) Reduce unwanted bystander editing
3) Minimize off-target activity
1) Increase on-target corrective editing
2) Reduce unwanted bystander editing
3) Minimize off-target activity
October 28, 2025 at 7:36 PM
Across multiple disease-relevant targets, we found that chimeric RNA:DNA hybrid guides can — both in vitro and in vivo —
1) Increase on-target corrective editing
2) Reduce unwanted bystander editing
3) Minimize off-target activity
1) Increase on-target corrective editing
2) Reduce unwanted bystander editing
3) Minimize off-target activity