Marco Pompili
@mnpompili.bsky.social
Pretending to be a behavior/systems neuroscientis
💡 Why it matters: understanding how context fear is regulated after extinction helps explain the limits of extinction-based therapies.
🙏 Thanks to all the authors — in particular Bill Godsil who set up the whole project and Adam Eckmier who made most of the experimental work. 🧵 5/5
🙏 Thanks to all the authors — in particular Bill Godsil who set up the whole project and Adam Eckmier who made most of the experimental work. 🧵 5/5
October 27, 2025 at 10:32 AM
💡 Why it matters: understanding how context fear is regulated after extinction helps explain the limits of extinction-based therapies.
🙏 Thanks to all the authors — in particular Bill Godsil who set up the whole project and Adam Eckmier who made most of the experimental work. 🧵 5/5
🙏 Thanks to all the authors — in particular Bill Godsil who set up the whole project and Adam Eckmier who made most of the experimental work. 🧵 5/5
📊 Stimulating vHPC→mPFC projections during context exposure after cued extinction we
• Observed decreased contextual fear
• Found no effects on motricity or contextual fear immediately after conditioning
➡️ Thus, vHPC–PL projections also modulate contextual fear expression after extinction. 🧵 4/5
• Observed decreased contextual fear
• Found no effects on motricity or contextual fear immediately after conditioning
➡️ Thus, vHPC–PL projections also modulate contextual fear expression after extinction. 🧵 4/5
October 27, 2025 at 10:32 AM
📊 Stimulating vHPC→mPFC projections during context exposure after cued extinction we
• Observed decreased contextual fear
• Found no effects on motricity or contextual fear immediately after conditioning
➡️ Thus, vHPC–PL projections also modulate contextual fear expression after extinction. 🧵 4/5
• Observed decreased contextual fear
• Found no effects on motricity or contextual fear immediately after conditioning
➡️ Thus, vHPC–PL projections also modulate contextual fear expression after extinction. 🧵 4/5
Previous work showed vHPC→prelimbic (PL) activity regulates cue-related fear after extinction.
But whether this pathway also controls contextual fear was unknown.
So we tested it directly 👇 🧵 3/5
But whether this pathway also controls contextual fear was unknown.
So we tested it directly 👇 🧵 3/5
October 27, 2025 at 10:32 AM
Previous work showed vHPC→prelimbic (PL) activity regulates cue-related fear after extinction.
But whether this pathway also controls contextual fear was unknown.
So we tested it directly 👇 🧵 3/5
But whether this pathway also controls contextual fear was unknown.
So we tested it directly 👇 🧵 3/5
📄 “Ventral hippocampus modulates prefrontal control of background contextual fear after cued extinction”
We looked at how the ventral hippocampus (vHPC) shapes prefrontal regulation of contextual fear after extinction. 🧵 2/5
We looked at how the ventral hippocampus (vHPC) shapes prefrontal regulation of contextual fear after extinction. 🧵 2/5
October 27, 2025 at 10:32 AM
📄 “Ventral hippocampus modulates prefrontal control of background contextual fear after cued extinction”
We looked at how the ventral hippocampus (vHPC) shapes prefrontal regulation of contextual fear after extinction. 🧵 2/5
We looked at how the ventral hippocampus (vHPC) shapes prefrontal regulation of contextual fear after extinction. 🧵 2/5