Mohammed Ahmed, Ph.D.
@mmahmedufl.bsky.social
Postdoctoral Researcher at the university of Florida | Bacterial Natural Products Biosynthesis | Genome Mining | Metabolomics
Happy to share my first publication as a postdoc in the Rudolf Lab at UF now published in Organic Letters!
Our study reports a single amino acid residue acts as a molecular switch controlling diterpene isomer product in a myxobacterial terpene synthase.
Here link: doi.org/10.1021/acs....
Our study reports a single amino acid residue acts as a molecular switch controlling diterpene isomer product in a myxobacterial terpene synthase.
Here link: doi.org/10.1021/acs....
A Single Residue Switch Controls Isomer Selectivity in the Myxobacterial Isobonnadiene Synthase
Myxobacterial terpenoids are rare and only a few myxobacterial terpene synthases are known. A terpene synthase, IbdS, from Polyangium aurulentum sp. SDU3-1 was found to produce the Δ9,10 isomer (1) of the spirocyclic 6/7/5-tricyclic bonnadiene, along with several 6/10-eunicellanes and cembrenoids as minor products. Sequence comparison and site-directed mutagenesis of IbdS and the actinobacterial bonnadiene synthase revealed a single residue switch at position 57 controlling isomer selectivity.
doi.org
February 6, 2026 at 12:48 AM
Happy to share my first publication as a postdoc in the Rudolf Lab at UF now published in Organic Letters!
Our study reports a single amino acid residue acts as a molecular switch controlling diterpene isomer product in a myxobacterial terpene synthase.
Here link: doi.org/10.1021/acs....
Our study reports a single amino acid residue acts as a molecular switch controlling diterpene isomer product in a myxobacterial terpene synthase.
Here link: doi.org/10.1021/acs....