Mariike Kuijjer
@mkuijjer.bsky.social
Associate Professor in Cancer Data Science at iCAN, University of Helsinki, Group leader in Computational Biology and Systems Medicine at NCMBM, University of Oslo. Research focus on precision network medicine in cancer.
Not a bad place to work 🍂🍁🌥🇩🇪
November 14, 2025 at 10:49 AM
Not a bad place to work 🍂🍁🌥🇩🇪
Would you like to model and analyze sample-specific regulatory networks? Check out our latest BioRxiv pre-print in which we present 𝐒𝐢𝐒𝐚𝐍𝐀, a command line workflow that makes modeling and analysis of single-sample networks really easy, transparent, and reproducible 🪄: www.biorxiv.org/content/10.1...
November 13, 2025 at 9:24 AM
Would you like to model and analyze sample-specific regulatory networks? Check out our latest BioRxiv pre-print in which we present 𝐒𝐢𝐒𝐚𝐍𝐀, a command line workflow that makes modeling and analysis of single-sample networks really easy, transparent, and reproducible 🪄: www.biorxiv.org/content/10.1...
This work presents a major milestone by the group, led by Tatiana Belova, with contributions from current and former group members. Funding sources incl the Norwegian Research Council, Norwegian Cancer Society, iCAN, and NCMBM 🙏 Code is available in Snakemake 🐍 pipeline: github.com/kuijjerlab/P...
October 7, 2025 at 1:42 PM
This work presents a major milestone by the group, led by Tatiana Belova, with contributions from current and former group members. Funding sources incl the Norwegian Research Council, Norwegian Cancer Society, iCAN, and NCMBM 🙏 Code is available in Snakemake 🐍 pipeline: github.com/kuijjerlab/P...
Finally, we mapped TFs modulating PD-L1, with their regulatory profiles linked to survival. Recurrent TFs included both known modulators (incl with/without known binding sites) and TFs with yet unknown role in PD-L1 regulation, highlighting candidate targets for modulating immune checkpoint activity
October 7, 2025 at 1:42 PM
Finally, we mapped TFs modulating PD-L1, with their regulatory profiles linked to survival. Recurrent TFs included both known modulators (incl with/without known binding sites) and TFs with yet unknown role in PD-L1 regulation, highlighting candidate targets for modulating immune checkpoint activity
Strikingly, PD1 signaling heterogeneity associated with survival in about half of these (12/23) cancer types, but only associated with immune infiltrate in a subset (5/12, 👇), suggesting that, in many cancers, dysregulation may arise from tumor-intrinsic regulatory programs
October 7, 2025 at 1:42 PM
Strikingly, PD1 signaling heterogeneity associated with survival in about half of these (12/23) cancer types, but only associated with immune infiltrate in a subset (5/12, 👇), suggesting that, in many cancers, dysregulation may arise from tumor-intrinsic regulatory programs
This motivated us to map the regulatory heterogeneity per cancer type with our tool PORCUPINE, analyzing the complete networks. This identified several recurrently heterogeneously regulated pathways (categories and pathways from top category 👇), with PD1 signaling dysregulated in 23/33 cancer types!
October 7, 2025 at 1:42 PM
This motivated us to map the regulatory heterogeneity per cancer type with our tool PORCUPINE, analyzing the complete networks. This identified several recurrently heterogeneously regulated pathways (categories and pathways from top category 👇), with PD1 signaling dysregulated in 23/33 cancer types!
We reconstructed sample-specific networks with our NetZoo tools PANDA and LIONESS: nearly 10k networks for 33 cancer types. Visualizing and clustering these networks on Gene Targeting Scores indicated that, for most cancer types, networks stratify patients distinctly from expression data (e.g. 👇)
October 7, 2025 at 1:42 PM
We reconstructed sample-specific networks with our NetZoo tools PANDA and LIONESS: nearly 10k networks for 33 cancer types. Visualizing and clustering these networks on Gene Targeting Scores indicated that, for most cancer types, networks stratify patients distinctly from expression data (e.g. 👇)
Until now, patient-specific regulatory networks have mostly been studied in individual cancer types. In our latest BioRxiv pre-print, we took this to the next level, performing a large-scale, pan-cancer network analysis of patient-specific regulatory landscapes: www.biorxiv.org/content/10.1...
October 7, 2025 at 1:42 PM
Until now, patient-specific regulatory networks have mostly been studied in individual cancer types. In our latest BioRxiv pre-print, we took this to the next level, performing a large-scale, pan-cancer network analysis of patient-specific regulatory landscapes: www.biorxiv.org/content/10.1...
Poster discussion ongoing, with our iCANDOC PhD student Panos presenting benchmarking of single sample network subtyping 📜
September 25, 2025 at 2:06 PM
Poster discussion ongoing, with our iCANDOC PhD student Panos presenting benchmarking of single sample network subtyping 📜
Nice location for the iCAN 2025 symposium!
September 25, 2025 at 2:06 PM
Nice location for the iCAN 2025 symposium!
Great spot for a pause and outdoor dinner in between work and dance, in beautiful Copenhagen 🧜♀️🇩🇰
September 17, 2025 at 7:41 PM
Great spot for a pause and outdoor dinner in between work and dance, in beautiful Copenhagen 🧜♀️🇩🇰
Touring the Nordics and Europe for science in early fall brings sundogs, rainbows, and beautiful clouds 🇸🇪🇫🇮🇩🇪🇳🇴🇩🇰 Also good to have packed rain gear 🚲🌦
September 16, 2025 at 4:13 PM
Touring the Nordics and Europe for science in early fall brings sundogs, rainbows, and beautiful clouds 🇸🇪🇫🇮🇩🇪🇳🇴🇩🇰 Also good to have packed rain gear 🚲🌦
Back from a wonderful joint group retreat in Fornebu 🌊🇳🇴 We had lots of pork neck, 🌶️ gossip, and fruitful discussions. Hope to do this again soon to keep connections strong 💪 So lucky to be part of this brilliant team of scientists 💫 Read more here: www.kuijjerlab.org/blog/group-r...
August 24, 2025 at 4:27 PM
Back from a wonderful joint group retreat in Fornebu 🌊🇳🇴 We had lots of pork neck, 🌶️ gossip, and fruitful discussions. Hope to do this again soon to keep connections strong 💪 So lucky to be part of this brilliant team of scientists 💫 Read more here: www.kuijjerlab.org/blog/group-r...
At the Meilahti campus bus stop, on my way to the group retreat in Fornebu 😍
August 20, 2025 at 2:09 PM
At the Meilahti campus bus stop, on my way to the group retreat in Fornebu 😍
Sundog above Helsinki 🌈🌥🇫🇮
August 4, 2025 at 6:00 PM
Sundog above Helsinki 🌈🌥🇫🇮
Beautiful halo on my ride home 🇫🇮🌥
July 1, 2025 at 5:51 PM
Beautiful halo on my ride home 🇫🇮🌥
Join us tomorrow at noon to learn more on spatial tumor ecosystems from @afarkkila.bsky.social from @farkkilab.bsky.social ! The talk will be at Forum, @forskningsparken.bsky.social
May 26, 2025 at 3:34 PM
Join us tomorrow at noon to learn more on spatial tumor ecosystems from @afarkkila.bsky.social from @farkkilab.bsky.social ! The talk will be at Forum, @forskningsparken.bsky.social
Missing the Network Zoo, I got myself some panda keys for my Oslo office 🐼🎍
May 23, 2025 at 10:27 AM
Missing the Network Zoo, I got myself some panda keys for my Oslo office 🐼🎍
On my way back to Oslo. I moved the NetZoo earlier in May to cheer up my new office in Helsinki 🙂 Will have to miss these until June!
May 14, 2025 at 11:23 AM
On my way back to Oslo. I moved the NetZoo earlier in May to cheer up my new office in Helsinki 🙂 Will have to miss these until June!
We were recently joined by three new group members. Welcome visiting PhD students Liangwei Yin and Iga Niemiec and co-supervised PhD student Ziqi Kang! For more info, see www.kuijjerlab.org/people/
May 11, 2025 at 10:17 AM
We were recently joined by three new group members. Welcome visiting PhD students Liangwei Yin and Iga Niemiec and co-supervised PhD student Ziqi Kang! For more info, see www.kuijjerlab.org/people/
Pretty spring colors from my Oslo office. Happy Easter 🐰 🐣 🌿
April 16, 2025 at 10:37 AM
Pretty spring colors from my Oslo office. Happy Easter 🐰 🐣 🌿
A warm welcome, science in Italian, and amazing coffee right next to the University—one of the main highlights of my visit to Benevento! This should be a must at every faculty 😁☕️
March 18, 2025 at 5:22 PM
A warm welcome, science in Italian, and amazing coffee right next to the University—one of the main highlights of my visit to Benevento! This should be a must at every faculty 😁☕️
I've been traveling so much lately that Oslo airport feels like my third home. Off to visit the University of Sannio in Benevento 🇮🇹☀️ Looking forward to discussing science and seeing new places!
March 16, 2025 at 11:10 AM
I've been traveling so much lately that Oslo airport feels like my third home. Off to visit the University of Sannio in Benevento 🇮🇹☀️ Looking forward to discussing science and seeing new places!
New beast in my Helsinki office 😃
February 14, 2025 at 2:25 PM
New beast in my Helsinki office 😃
Importantly, 𝑟𝑒𝑡𝑟𝑖𝑒𝑣𝑒𝑟 can be applied to data from individual patients. The top predicted drugs ranked highly in most patients, but other top-ranked drugs or combinations could offer insights into potential patient-specific treatment strategies 🎯
February 12, 2025 at 9:23 AM
Importantly, 𝑟𝑒𝑡𝑟𝑖𝑒𝑣𝑒𝑟 can be applied to data from individual patients. The top predicted drugs ranked highly in most patients, but other top-ranked drugs or combinations could offer insights into potential patient-specific treatment strategies 🎯