MJ´s lab
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mjslab.bsky.social
MJ´s lab
@mjslab.bsky.social
Studying the molecular mechanisms underlying cerebral ischemia at
UAM_Madrid #Neurodegeneration #Glia #Oligodendrocytes #Myelin #Stroke #Brain
Hi everyone!

Take a look at our review:

"Dysregulation of mTOR Signaling after Brain Ischemia"

www.mdpi.com/1422-0067/23...
Dysregulation of mTOR Signaling after Brain Ischemia
In this review, we provide recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, with a particular focus on cerebral ischemia. We cover the upstream and ...
www.mdpi.com
January 13, 2025 at 2:35 PM
Happy to share with you our publication in Biology Direct on the use of Rapamycin as a modulator of microglial response following ischemic stroke.

Hope you find it interesting!

biologydirect.biomedcentral.com/articles/10....
Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity - Biology Direct
Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation i...
biologydirect.biomedcentral.com
January 13, 2025 at 2:32 PM
Very pleased to share with you the latest publication conducted in our laboratory. It describes an endogenous mechanism of brain tissue repair mediated by oligodendrocytes following cerebral ischemia.

I hope you find it interesting!

www.sciencedirect.com/science/arti...
The dynamics of oligodendrocyte populations following permanent ischemia promotes long-term spontaneous remyelination of damaged area
Stroke is a major public health concern, with limited clinically approved interventions available to enhance sensorimotor recovery beyond reperfusion.…
www.sciencedirect.com
January 13, 2025 at 2:30 PM
Hi everyone!

It is a pleasure to share with you our review:

"Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury"

www.mdpi.com/2073-4409/10...
Glial Cells as Therapeutic Approaches in Brain Ischemia-Reperfusion Injury
Ischemic stroke is the second cause of mortality and the first cause of long-term disability constituting a serious socioeconomic burden worldwide. Approved treatments include thrombectomy and rtPA in...
www.mdpi.com
January 13, 2025 at 2:28 PM