Marijn Schipper
@mjschipper.bsky.social
Geneticist, Programmer and Science Enthousiast
We use FLAMES to prioritize 180 schizophrenia risk genes. We find that these genes are highly enriched in synaptic functions.
Clustering these genes based on relative expression throughout the lifetime shows that about one third of these genes are expressed strongest prenatally.
Clustering these genes based on relative expression throughout the lifetime shows that about one third of these genes are expressed strongest prenatally.
February 11, 2025 at 9:58 AM
We use FLAMES to prioritize 180 schizophrenia risk genes. We find that these genes are highly enriched in synaptic functions.
Clustering these genes based on relative expression throughout the lifetime shows that about one third of these genes are expressed strongest prenatally.
Clustering these genes based on relative expression throughout the lifetime shows that about one third of these genes are expressed strongest prenatally.
We benchmark our method against multiple tools, in different datasets (2 largest in fig). We find that FLAMES consistently outperforms other current gene prioritization methods.
Expert-curated = subset from: pubmed.ncbi.nlm.nih.gov/34711957/
ExWAS implicated from: pubmed.ncbi.nlm.nih.gov/37009933/
Expert-curated = subset from: pubmed.ncbi.nlm.nih.gov/34711957/
ExWAS implicated from: pubmed.ncbi.nlm.nih.gov/37009933/
February 11, 2025 at 9:58 AM
We benchmark our method against multiple tools, in different datasets (2 largest in fig). We find that FLAMES consistently outperforms other current gene prioritization methods.
Expert-curated = subset from: pubmed.ncbi.nlm.nih.gov/34711957/
ExWAS implicated from: pubmed.ncbi.nlm.nih.gov/37009933/
Expert-curated = subset from: pubmed.ncbi.nlm.nih.gov/34711957/
ExWAS implicated from: pubmed.ncbi.nlm.nih.gov/37009933/
FLAMES annotates 95% credible sets from fine-mapped GWAS loci with functional data linking SNPs to genes from over 20 sources.
We did this with 1181 loci which contain a gene also implicated by rare pLoF variants. We find these pLoF ExWAS genes enriched in functional annotations from GWAS SNPs.
We did this with 1181 loci which contain a gene also implicated by rare pLoF variants. We find these pLoF ExWAS genes enriched in functional annotations from GWAS SNPs.
February 11, 2025 at 9:58 AM
FLAMES annotates 95% credible sets from fine-mapped GWAS loci with functional data linking SNPs to genes from over 20 sources.
We did this with 1181 loci which contain a gene also implicated by rare pLoF variants. We find these pLoF ExWAS genes enriched in functional annotations from GWAS SNPs.
We did this with 1181 loci which contain a gene also implicated by rare pLoF variants. We find these pLoF ExWAS genes enriched in functional annotations from GWAS SNPs.