Collectively, mapping the landscape of autosomal mCAs in populations of diverse ancestry illustrates similarities but also highlights important ancestry, geographic, and sex differences.

We also showed how mCAs impact blood transcriptomes, implicating stabilizing selection as a mechanism by which copy number gain mutations are tolerated in healthy blood.

We identified autosomal mCA hotspots that were ancestry- and sex-specific, mapped novel ancestry-specific germline variants associated with autosomal mCA prevalence, and estimated heritability rates to quantify the germline genetic contribution to autosomal mCA variance.

We profiled mCA, large chromosomal mosaic alterations in the blood of >60,000 participants European-descent and African cohorts, including a founding population cohort in Quebec, and individuals from within South, Central, West and East Africa.

I’ll take it as a compliment today ☺️ maybe this retinol cream is working 😅

Thanks your post made me realize how much I needed to hear that today ☺️