Milla Gois
@millagois.bsky.social
Brasileira morando na Holanda, PhD candidate, microbiome enthusiast
9/9 🌟 Our research provides a fresh perspective on pesticide exposure, demonstrating the intricate web of concurrent exposures and their influence on the human gut microbiome!🦠
Dive into the paper and discover the bigger picture! 📚🔍
https://t.co/K0henpUZVG
Dive into the paper and discover the bigger picture! 📚🔍
https://t.co/K0henpUZVG
Impact of occupational pesticide exposure on the human gut microbiome
The rising use of pesticides in modern agriculture has led to a shift in disease burden in which exposure to these chemicals plays an increasingly important role. The human gut microbiome, which is pa...
t.co
August 10, 2023 at 2:02 PM
9/9 🌟 Our research provides a fresh perspective on pesticide exposure, demonstrating the intricate web of concurrent exposures and their influence on the human gut microbiome!🦠
Dive into the paper and discover the bigger picture! 📚🔍
https://t.co/K0henpUZVG
Dive into the paper and discover the bigger picture! 📚🔍
https://t.co/K0henpUZVG
8/9 ⚠️ Importantly: occupational exposure estimates are not (and should not be) considered a direct readout of compound uptake!
🟢But, the reported associations between gut microbiome and exposures estimates shows the impact of these compounds yield on the human gut environment!
🟢But, the reported associations between gut microbiome and exposures estimates shows the impact of these compounds yield on the human gut environment!
August 10, 2023 at 2:02 PM
8/9 ⚠️ Importantly: occupational exposure estimates are not (and should not be) considered a direct readout of compound uptake!
🟢But, the reported associations between gut microbiome and exposures estimates shows the impact of these compounds yield on the human gut environment!
🟢But, the reported associations between gut microbiome and exposures estimates shows the impact of these compounds yield on the human gut environment!
7/9🧫 39 bacterial spp were significantly associated to exposure to at least 1 class of pesticides
🧐 Overall, pesticide exposures were associated with distinct presence/absence of specific bacteria. However, changes in the relative abundance of certain taxa were also observed!
🧐 Overall, pesticide exposures were associated with distinct presence/absence of specific bacteria. However, changes in the relative abundance of certain taxa were also observed!
August 10, 2023 at 2:01 PM
7/9🧫 39 bacterial spp were significantly associated to exposure to at least 1 class of pesticides
🧐 Overall, pesticide exposures were associated with distinct presence/absence of specific bacteria. However, changes in the relative abundance of certain taxa were also observed!
🧐 Overall, pesticide exposures were associated with distinct presence/absence of specific bacteria. However, changes in the relative abundance of certain taxa were also observed!
6/9 🦠What about the gut microbiome?
Drumroll, please! 🥁
Except for herbicides, exposure to all pesticide classes was significantly associated with a decreased alpha diversity and a distinct gut microbiome composition!
Drumroll, please! 🥁
Except for herbicides, exposure to all pesticide classes was significantly associated with a decreased alpha diversity and a distinct gut microbiome composition!
August 10, 2023 at 2:01 PM
6/9 🦠What about the gut microbiome?
Drumroll, please! 🥁
Except for herbicides, exposure to all pesticide classes was significantly associated with a decreased alpha diversity and a distinct gut microbiome composition!
Drumroll, please! 🥁
Except for herbicides, exposure to all pesticide classes was significantly associated with a decreased alpha diversity and a distinct gut microbiome composition!
5/9 📊In our cohort, 4.1% were assigned exposure to at least 1 pesticide class.
Males were predominant and, generally, estimates were of low-exposure. Length of employment was mostly >6 years.
This suggests a low-intensity, chronic profile of exposure.
The plot thickens!🤔
Males were predominant and, generally, estimates were of low-exposure. Length of employment was mostly >6 years.
This suggests a low-intensity, chronic profile of exposure.
The plot thickens!🤔
August 10, 2023 at 2:00 PM
5/9 📊In our cohort, 4.1% were assigned exposure to at least 1 pesticide class.
Males were predominant and, generally, estimates were of low-exposure. Length of employment was mostly >6 years.
This suggests a low-intensity, chronic profile of exposure.
The plot thickens!🤔
Males were predominant and, generally, estimates were of low-exposure. Length of employment was mostly >6 years.
This suggests a low-intensity, chronic profile of exposure.
The plot thickens!🤔
4/9🧪Estimates were classified in: No-, Low- and High-exposure.
Assessment was based on employment codes (ISCO) and a Job Exposure Matrix (ALOHA+).
🐜🌾 We looked at occupational exposures to 4 pesticide classes: Insecticides, Herbicides, Fungicides, and "General pesticides."
Assessment was based on employment codes (ISCO) and a Job Exposure Matrix (ALOHA+).
🐜🌾 We looked at occupational exposures to 4 pesticide classes: Insecticides, Herbicides, Fungicides, and "General pesticides."
August 10, 2023 at 1:59 PM
4/9🧪Estimates were classified in: No-, Low- and High-exposure.
Assessment was based on employment codes (ISCO) and a Job Exposure Matrix (ALOHA+).
🐜🌾 We looked at occupational exposures to 4 pesticide classes: Insecticides, Herbicides, Fungicides, and "General pesticides."
Assessment was based on employment codes (ISCO) and a Job Exposure Matrix (ALOHA+).
🐜🌾 We looked at occupational exposures to 4 pesticide classes: Insecticides, Herbicides, Fungicides, and "General pesticides."
3/9🎯Our goal was to explore the impact of occupational exposures to pesticides on the human gut microbiome
We selected 7198 participants from the DMP, a LifelinesNL subcohort. Job exposure estimates, gut microbiome, health and employment data were available for all participants
We selected 7198 participants from the DMP, a LifelinesNL subcohort. Job exposure estimates, gut microbiome, health and employment data were available for all participants
August 10, 2023 at 1:59 PM
3/9🎯Our goal was to explore the impact of occupational exposures to pesticides on the human gut microbiome
We selected 7198 participants from the DMP, a LifelinesNL subcohort. Job exposure estimates, gut microbiome, health and employment data were available for all participants
We selected 7198 participants from the DMP, a LifelinesNL subcohort. Job exposure estimates, gut microbiome, health and employment data were available for all participants
2/9 Delving into the world of environmental exposures can be tricky.
To date, most pesticide studies focus on specific compounds/dosages. Often, these products are administrated along with other pesticides and within varying dosages.
Here, we took a broader approach! 🕵️
To date, most pesticide studies focus on specific compounds/dosages. Often, these products are administrated along with other pesticides and within varying dosages.
Here, we took a broader approach! 🕵️
August 10, 2023 at 1:58 PM
2/9 Delving into the world of environmental exposures can be tricky.
To date, most pesticide studies focus on specific compounds/dosages. Often, these products are administrated along with other pesticides and within varying dosages.
Here, we took a broader approach! 🕵️
To date, most pesticide studies focus on specific compounds/dosages. Often, these products are administrated along with other pesticides and within varying dosages.
Here, we took a broader approach! 🕵️