Michael Crowther (he/him)
@mikecrowther.bsky.social
Post-Doctoral researcher working with genetically engineered Tumour Infiltrating Lymphocytes (TILs), based in Copenhagen, Denmark
In these disease sates, we see low HLA Class I expression, and high NK-cell abundance, along with other insights into the immune infiltrations that expand our knowledge of this rare form of cancer of the eye.
February 13, 2025 at 10:55 AM
In these disease sates, we see low HLA Class I expression, and high NK-cell abundance, along with other insights into the immune infiltrations that expand our knowledge of this rare form of cancer of the eye.
In this paper, we show the feasibility of analysing immune infiltrations in primary uveal melanoma, particularly in the less well studied low-risk disease that do not normally undergo enucleation, through the use of Transvitreal Retinochoroidal (fine needle) Biopsies.
February 13, 2025 at 10:55 AM
In this paper, we show the feasibility of analysing immune infiltrations in primary uveal melanoma, particularly in the less well studied low-risk disease that do not normally undergo enucleation, through the use of Transvitreal Retinochoroidal (fine needle) Biopsies.
They are similar to MAIT cells only in that they recognise MR1, so we don't think it is quite correct to call them MAIT. But they're definitely in the same family!
January 7, 2025 at 10:49 AM
They are similar to MAIT cells only in that they recognise MR1, so we don't think it is quite correct to call them MAIT. But they're definitely in the same family!
MAIT cell are defined by their expression of CD161 and having a TRAV1-2 containing TCR-alpha chain, and are highly present in the mucosa. These cancer-restricted T-cells do not posses any of these properties.
January 3, 2025 at 10:04 AM
MAIT cell are defined by their expression of CD161 and having a TRAV1-2 containing TCR-alpha chain, and are highly present in the mucosa. These cancer-restricted T-cells do not posses any of these properties.