Miheer
@miheerp.bsky.social
Heme/onc. Was never that into Twitter, so we’ll see if the skies stay blue. I guess I’ll start by posting info I find useful in everyday clinical practice. #MedSky #HemeSky #OncSky
Probably yes, but in reading up on it I realized the data isn’t as robust as pharm ppx in other settings, that for DOACs we’re extrapolating from this already slim data base, and that compression stockings actually have a fair amount of data!
November 20, 2024 at 2:30 AM
Probably yes, but in reading up on it I realized the data isn’t as robust as pharm ppx in other settings, that for DOACs we’re extrapolating from this already slim data base, and that compression stockings actually have a fair amount of data!
To quantify that a bit - in the LONFLIT3 trial the rate of recurrent VTE for high risk travelers was:
No ppx: 4.8%
ASA: 3.6%
LMWH: none
There’s probably stronger data for compression stockings than aspirin, though I don’t think they have been directly compared.
pubmed.ncbi.nlm.nih.gov/11863301/
No ppx: 4.8%
ASA: 3.6%
LMWH: none
There’s probably stronger data for compression stockings than aspirin, though I don’t think they have been directly compared.
pubmed.ncbi.nlm.nih.gov/11863301/
Venous thrombosis from air travel: the LONFLIT3 study--prevention with aspirin vs low-molecular-weight heparin (LMWH) in high-risk subjects: a randomized trial - PubMed
The LONFLIT1 and 2 studies established that in high-risk subjects after long (>10 hours) flights, the incidence of deep venous thrombosis (DVT) may be between 4% and 6%, The LONFLIT3 study aimed to ev...
pubmed.ncbi.nlm.nih.gov
November 17, 2024 at 1:38 PM
To quantify that a bit - in the LONFLIT3 trial the rate of recurrent VTE for high risk travelers was:
No ppx: 4.8%
ASA: 3.6%
LMWH: none
There’s probably stronger data for compression stockings than aspirin, though I don’t think they have been directly compared.
pubmed.ncbi.nlm.nih.gov/11863301/
No ppx: 4.8%
ASA: 3.6%
LMWH: none
There’s probably stronger data for compression stockings than aspirin, though I don’t think they have been directly compared.
pubmed.ncbi.nlm.nih.gov/11863301/
From an EBM perspective there isn’t much beyond the standard “walk around occasionally and stay hydrated” for those who aren’t in one of those high risk groups.
Practically there’s little risk to a dose of aspirin for most people, but there’s also little benefit in preventing VTE.
Practically there’s little risk to a dose of aspirin for most people, but there’s also little benefit in preventing VTE.
November 17, 2024 at 1:38 PM
From an EBM perspective there isn’t much beyond the standard “walk around occasionally and stay hydrated” for those who aren’t in one of those high risk groups.
Practically there’s little risk to a dose of aspirin for most people, but there’s also little benefit in preventing VTE.
Practically there’s little risk to a dose of aspirin for most people, but there’s also little benefit in preventing VTE.
The data for LMWH is limited to one RCT, and despite there being no prospective data for DOACs it’s reasonable to think they would work just as well.
This ASH clinical news article delves into DOACs, and some of the myths about VTE and travel.
ashpublications.org/ashclinicaln...
This ASH clinical news article delves into DOACs, and some of the myths about VTE and travel.
ashpublications.org/ashclinicaln...
Planes, Trains, and VTEs | ASH Clinical News | American Society of Hematology
ashpublications.org
November 17, 2024 at 1:54 AM
The data for LMWH is limited to one RCT, and despite there being no prospective data for DOACs it’s reasonable to think they would work just as well.
This ASH clinical news article delves into DOACs, and some of the myths about VTE and travel.
ashpublications.org/ashclinicaln...
This ASH clinical news article delves into DOACs, and some of the myths about VTE and travel.
ashpublications.org/ashclinicaln...
Although the data isn’t robust, the 2018 ASH VTE guidelines give some suggestions:
A) for the average person: no ppx
B) if high risk and travel >4h: compression stockings OR LMWH ppx.
(If unable to do either of those, full dose aspirin is better than nothing)
ashpublications.org/bloodadvance...
A) for the average person: no ppx
B) if high risk and travel >4h: compression stockings OR LMWH ppx.
(If unable to do either of those, full dose aspirin is better than nothing)
ashpublications.org/bloodadvance...
November 17, 2024 at 1:54 AM
Although the data isn’t robust, the 2018 ASH VTE guidelines give some suggestions:
A) for the average person: no ppx
B) if high risk and travel >4h: compression stockings OR LMWH ppx.
(If unable to do either of those, full dose aspirin is better than nothing)
ashpublications.org/bloodadvance...
A) for the average person: no ppx
B) if high risk and travel >4h: compression stockings OR LMWH ppx.
(If unable to do either of those, full dose aspirin is better than nothing)
ashpublications.org/bloodadvance...