Miguel Miranda, Ph.D.
@miguel-miranda.bsky.social
Biomedical Scientist, Cancer Biology. 👨🔬 Científico #Boricua 🇵🇷 Views=Own
This is great! Would love to join as well.
November 25, 2024 at 1:27 PM
This is great! Would love to join as well.
4/ I’m deeply grateful to my collaborators and mentors who made this work possible.
The full paper is available here: aacrjournals.org/clincancerre.... I’d love to hear your thoughts!
#AACR #Publication #Teamwork
The full paper is available here: aacrjournals.org/clincancerre.... I’d love to hear your thoughts!
#AACR #Publication #Teamwork
MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
AbstractPurpose:. Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. L...
aacrjournals.org
November 25, 2024 at 10:42 AM
4/ I’m deeply grateful to my collaborators and mentors who made this work possible.
The full paper is available here: aacrjournals.org/clincancerre.... I’d love to hear your thoughts!
#AACR #Publication #Teamwork
The full paper is available here: aacrjournals.org/clincancerre.... I’d love to hear your thoughts!
#AACR #Publication #Teamwork
3/ To overcome this resistance, we found that combining MEK inhibitors with PDGFR/RAF-dimer inhibitors can improve treatment response.
This highlights a promising new strategy for tackling MPNST!
#TargetedTherapy #Research
This highlights a promising new strategy for tackling MPNST!
#TargetedTherapy #Research
November 25, 2024 at 10:42 AM
3/ To overcome this resistance, we found that combining MEK inhibitors with PDGFR/RAF-dimer inhibitors can improve treatment response.
This highlights a promising new strategy for tackling MPNST!
#TargetedTherapy #Research
This highlights a promising new strategy for tackling MPNST!
#TargetedTherapy #Research
2/ In our study, we show how NF1-deficient malignant peripheral nerve sheath tumors (MPNSTs) develop adaptive resistance to MEK inhibitors by upregulating PDGFRβ transcription and increasing RAF dimer formation.
#CancerResearch #MPNST
#CancerResearch #MPNST
November 25, 2024 at 10:42 AM
2/ In our study, we show how NF1-deficient malignant peripheral nerve sheath tumors (MPNSTs) develop adaptive resistance to MEK inhibitors by upregulating PDGFRβ transcription and increasing RAF dimer formation.
#CancerResearch #MPNST
#CancerResearch #MPNST