Kirsty Wan
banner
micromotility.bsky.social
Kirsty Wan
@micromotility.bsky.social
Cilia and cell motility enthusiast, basal cognition, weird organisms esp protists and larvae, how do living systems compute?

Professor of Cellular & Biophysical Dynamics, Living Systems Institute, Exeter (past: DAMTP, Cambridge)

www.micromotility.com
congrats! beautiful work!
November 10, 2025 at 3:21 PM
Cool! I didn't even know about #wormwednesday!
October 15, 2025 at 9:20 PM
Yeah okay i agree... I just like to provoke horror from @jekely.biologists.social.ap.brid.gy

Thanks!!
October 15, 2025 at 9:19 PM
Our findings highlight a remarkably modular and robust propulsion mechanism found in a marine larva, which relies on short-range physical interactions to achieve ciliary coordination.

Thanks to Rebecca for all the hard work and @jekely.biologists.social.ap.brid.gy for the collaboration!
October 15, 2025 at 8:53 PM
#platynereis is an excellent model for cilia dynamics and coordination, incl. how metachronal waves emerge - during a process known as ciliary closure. These events are neuronal controlled, allowing the larvae to finely control their position in the water column elifesciences.org/articles/26000
October 15, 2025 at 8:53 PM
in fact, you can just keep removing cilia, until all but a single wavelength of the ciliary band remains. The tiny patch keeps propagating a metachronal wave! [watch video till the end]
(see paper for other interesting details about these waves)
October 15, 2025 at 8:53 PM
to test if spatial gaps could break wave transmission, we (Rebecca) started removing more and more cilia from this equatorial ring, finding that spatial continuity of the cilia within a single multiciliated cell is both necessary and sufficient for wave continuity
October 15, 2025 at 8:53 PM
look at the discontinuities in the following kymograph (space-time plot of beat phase), turns out these come from the natural gaps between neighbouring multiciliated cells (each with several hundred cilia!).
October 15, 2025 at 8:53 PM
with a single equatorial band made up of many many cilia. These propagate so-called 'metachronal waves', always in the same direction! The wave may look continuous, but in fact it's not!
October 15, 2025 at 8:53 PM
What is a #Platynereis you might ask? I would never have encountered them were it not for @jekely.biologists.social.ap.brid.gy

The adult worm is extremely ugly, in contrast, the larvae, is adorned with many cilia, which naturally makes them beautiful. The 2-day old larva is approximately spherical
October 15, 2025 at 8:53 PM