Michelle Jansman
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michellejansman.bsky.social
Michelle Jansman
@michellejansman.bsky.social
300 followers 190 following 50 posts
Researcher at DTU Health Tech and Stanford School of Medicine | Nanoparticle formulation | Oxygen carriers | Tissue engineering
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michellejansman.bsky.social
I had a great time attending and presenting my work at #BMES2025 in San Diego. It was such a nice opportunity to talk about my and others' projects on bone tissue engineering. Thank you everyone for the great talks! 🧪👩‍🔬
Presenting my project on Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels. Sunset view at BMES 2025
October 15, 2025 at 7:49 PM
michellejansman.bsky.social
Excited to be attending #BMES2025!

I will be presenting my work on fabricating oxygen releasing scaffolds for bone tissue engineering in Friday's poster session (T37). Interested in targeting hypoxia, hemoglobin-based oxygen carriers, or bone TE? Please come say hi 😀

🧪👩‍🔬
Poster T37. Modulating oxygen tension in bone tissue engineering via hemoglobin-loaded microribbon hydrogels.
October 10, 2025 at 12:32 AM
michellejansman.bsky.social
Attended an interesting talk by Prof. Derek Amanatullah (Stanford Med), discussing dormant infections in joint replacements. Concl.: MPS-mediated response as biomarker enables better screening and patient prognosis.

doi.org/10.1186/s129...

#AcademicSky #MedSky 🧪
@stanfordmedicine.bsky.social
The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements, by Manasherob et al. Published in the Journal of Tranlational medicine, 2024. https://doi.org/10.1186/s12967-024-05866-5. Below: Schematic understanding of dormant infection (green) as an MPS-mediated IL17 response to biofilm inhibiting PMN recruitment and function when compared to patients with (red) or without (blue) and active infection.
April 18, 2025 at 8:56 PM
michellejansman.bsky.social
Fully agree with this piece 🧪
In the past, I've contacted a Prof that miscited my paper (we did do the research, just in another ref). No response..

I think the reason is the long process of corrections post publ. So, better to ignore. Wrong citations should be treated easier, it will help everyone
Part of the article: Peer review cannot realistically verify every reference. There simply is not enough time. Today, targeted AI tools could potentially help detect mis-citations or odd citation patterns, making the work more robust [4]. Journals should also offer a clear, low-friction process for post-publication corrections. A publication should not be set in stone after proofs. A formal reporting mechanism must allow authors to challenge and fix citation errors without needing the citing author’s approval.
March 18, 2025 at 4:16 PM
michellejansman.bsky.social
Another TissueTalk is online, this time with with Prof. Warren Grayson (John Hopkins U, US)🧪
www.youtube.com/watch?v=yNuK...

Gave a clear introduction to the use of scRNA-seq in deciphering cells’ expressions during bone regeneration. Looking forward to reading the article on this.

#biomaterials
Summary slide from the TissueTalk given by Prof. Warren Grayson. Shows that 1) Multimodal imaging and QLS provide rich dataset that illuminate the interplay between vasculature and bone. 2) Adapted QLSM imaging and analysis pipeline used to elucidate aging neural dynamics. 3) Single cell sequencing revealed proliferative factors that may be signaling to osteoprogenitors to maintain stemness in critical-sized defects.
March 10, 2025 at 5:36 PM
michellejansman.bsky.social
New review paper on artificial O2 carriers by Mohanto et al (Shosun U, KR)🧪
-Products: Hb-, PFC-, stem cell-, bubble-based O2 carriers
-Targets incl: anemia, tumor hypoxia, hemor. shock, tissue regeneration, organ preservation
-Finishes with key considerations for future

doi.org/10.1186/s129...
Paper: Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases, by Mohanto et al. Published in Journal of Nanobiotechnology, 2025. https://doi.org/10.1186/s12951-024-03060-9 TOC shows the four discussed products: hemoglobin-, perfluorocarbon-, stem cell-, and micro/nanobubble-based oxygen carriers. For each product, various disease models are targeted. These include i.a. hemorrhagic shock, oxygen preservation, tumor hypoxia, respiratory failure, stroke, chronic hypoxia, and sickle cell crisis. Fig 9 shows the required goals for the perfect O2 carrier. Include i.a. efficient O2 release, extended half-life, innate to inflammatory system, and no acute or long-term toxicities.
March 4, 2025 at 4:42 PM
michellejansman.bsky.social
Another way to showcase the group's research👩‍🎨🧪

www.fanyanggroup.com/paintourrese...
Visit the site to see all 14 paintings (and maybe more to come!)
#AcademicSky
Paint Our Research page on the Fan Yang Lab website. Showing the first three painings called: Tree of Life, Conversations, and the Crabs Cycle
February 28, 2025 at 9:53 PM
michellejansman.bsky.social
New HBOC paper out by the Komatsu group (Chuo U, JP)🧪
- HSA-coated SFHbNPs (30 nm), to evade RES
- NPs shows good functionality, with p50=8 Torr
- Full resuscitation in hemorrhagic shock model, with similar results as the shed autologous blood (SAB) control

doi.org/10.1021/acsa...
#chemsky
Paper: Nanoparticle O2 Carrier Composed of a Polymerized Stroma-Free Hemoglobin Core and Serum Albumin Shell as a Red Blood Cell Alternative in Hemorrhagic Shock Therapy, by Kohyama et al. 2025, ACS Applied bio materials. https://doi.org/10.1021/acsabm.4c01901 TOC showing SFHbNPs product in solution, schematic of the NP system and the in vivo model. Fig 3. (A) Visible absorption spectral changes of SFHbNP at 25 °C (in PBS, pH 7.4). (B) O2 dissociation curves of SFHbNP, Hb, and RBC at37 °C (in PBS, pH 7.4). Fig 4. Changes in (A) survival rate and (B) MAP in anesthetized rats during the hemorrhagic shock and following resuscitation with SFHbNP solution ([Hb] = 5 g dL−1, in PBS with 3 g dL−1 HSA, pH 7.4) and controls (SAB, RL).
February 24, 2025 at 5:35 PM
michellejansman.bsky.social
New paper by Alayash’s group (FDA, CBER center, US), on improving blood storage using curcumin-based formulations.🧪 Incl: biopreservation of RBC membrane integrity, redox balance, and increased longevity in circulation.
https://doi.org/10.1038/s41598-024-82943-1

oxygen delivery #Biomaterials
Paper: Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation, by Hicks et all, published in Scientific reports 2024. https://doi.org/10.1038/s41598-024-82943-1 Figure 4. Post-transfusion recovery rates of RBCs and other bioenergetics and hematological induces in guinea pigs. (A) 24-hour post-transfusion recovery rates of RBCs stored conventionally and with curcumin supplementation over a storage period of 2 to 3 weeks. The hematocrit levels (B), hemolysis rate (C), ATP levels (D), and 2,3-DPG concentrations (E) over time. Figure 5. Curcumin downregulates fibrinogen and prevents RBC aggregation. Proposed model for the interaction of curcumin with fibrinogen to prevent aggregation of aged RBCs
February 18, 2025 at 1:29 AM
michellejansman.bsky.social
Watched last week’s TissueTalk with Prof. Irv Weissman (@StanfordMed, US)🧪

Was especially interested to hear the origin of the ‘don’t eat me/eat me’ signaling of CD47, which is something we wanted to explore with our membrane-coated HBOC NPs as well (1/2).

Online: www.youtube.com/watch?v=dKnA...
Slide of presentation of TissueTalk with Prof. Irv Weissman. Shows a schematic of the Don’t eat me/eat me mechanism. https://doi.org/10.1126/scitranslmed.3001375 Slide of presentation of TissueTalk with Prof. Irv Weissman. Shows a summary of CD47 upregulation in various cells/diseases.
February 17, 2025 at 5:06 PM
michellejansman.bsky.social
New paper on Hb-loaded ZIF-8 NPs by Hosta-Rigau’s group (@DTU_HealthTech, DK)👩‍🔬. This is a continuation on previous work on ZIF-8 HBOCs, assessing their stability, catalytic activity and stealth properties. Happy to have contributed to this project! 🧪 https://buff.ly/42Uqb2q
Hemoglobin-loaded ZIF-8 NPs equipped with PEGylated metal-phenolic network coatings: an oxygen carrier with antioxidant and stealth properties, by Coll-Satue et al. Published in the Journal of Materials Chemistry B, 2025. https://doi.org/10.1039/d4tb01771d Scheme 2. Schematic illustration of the surface modifications of Hb-loaded ZIF-8 nanoparticles (Hb@ZIF-8 NPs). A MPN coating was deposited onto the Hb@ZIF-8 NPs, resulting in the formation of Hb@ZIF-8/MPN NPs. Subsequently, PLL and PEG were deposited onto the surface to obtain Hb@ZIF-8/MPN/PLL/PEG NPs. Fig. 4. Photographic images of NPs after centrifugation following 24 h of incubation at 4C Fig. 8. UV-vis spectra of oxygenated and deoxygenated Hb and NPs after successively purging with compressed air or nitrogen gas. The exact wavelengths for the Soret peak and Qbands are reported in the table. Fig. 10.a i Hemolysis rate of red blood cells after being incubated for 1 h with NPs #TissueEngineering #AcademicSky #Hemoglobin
February 13, 2025 at 4:58 PM
michellejansman.bsky.social
Just watched TissueTalk with Prof. Ellen Roche (MIT)👩‍🔬

She discusses i.a. how they use soft robotics for addressing end-stage heart failure (via a heart sleeve) and respiratory muscle weakness (via diaphragm support).🧪

Online: www.youtube.com/watch?v=3A2B...
#TissueEngineering
Slide of the presentation given by Prof. Ellen Roche, showing their research's Vision. 1. Support and repair organs with intrinsic mechanical function by designing solutions that integrate technology into the inherent complex biomechanics of the tissue. 2. Supplement or supplant current approaches by matching and supporting native organ function.
February 12, 2025 at 8:06 PM
michellejansman.bsky.social
Just got back from the annual lab retreat with the Fan Yang group @stanfordmedicine.bsky.social. 🧪👩‍🔬 What a great way to get introduced to all the amazing people and their projects this way!
And the locations wasn't bad either 😉 ☀️🦌

#academysky #biomaterials
Fan Yang lab retreat 2025, written in the sand with the sunset in the background Goody bag included the Lab retreat brochure, a book from Peter Attia (outlive the science and art of longevity), and a new desk mascot: the pamper pineapple. Deers on the conference grounds near the conference hall
February 12, 2025 at 6:32 PM
michellejansman.bsky.social
My first week at @stanfordmedicine.bsky.social:
- Giving a presentation about HBOCs🧪👩‍🔬, explaining that there is a lack of available donor blood
- Receiving the Stanford Report, encouraging people to donate blood

The coincidence is amazing. It’s great to see the active approach they are having here!
On top, the introduction slide of a presentation regarding Hemoglobin-based oxygen carriers with antioxidant properties. Based on research at DTU Health Tech (Technical University of Denmark). In the bottom, the banner from Stanford Blood center. Give blood in february, and you could win tickets to see Coldplay or Shakira in concert. Link: https://stanfordbloodcenter.org/music-lovers-february/
February 7, 2025 at 5:31 PM
michellejansman.bsky.social
Weekendavisen just published an article regarding artificial blood substitutes, with an interview with Prof. Leticia Hosta-Rigau at DTU Health Tech.
Very nice to see our research reach the Danish news!
www.weekendavisen.dk/2025-04/idee...

🧪👩‍🔬 #HBOCs #AcademicSky
Title and image of the news article: at blande blod. With an image of dried red powder slowly droplet-wise changing into a red blood-like liquid.
January 29, 2025 at 9:55 AM
michellejansman.bsky.social
Wakabayashi et al. (Chuo Uni, Japan) uses PROx as alternative to PEG in HBOCs design.
* Polymer conjugation does not alter Hb folding
* T- and R-state synthesis allows for p50 modulation
* PROx-Hbs have lower viscosity than corresponding PEG-Hbs

🧪 #chemsky
Paper: Synthesis and Physicochemical Properties of Poly(2-Alkyl-2-Oxazoline)-Conjugated Hemoglobins as an Artificial Oxygen Carrier: Comparison with Polyethylene Glycol Conjugates, in Macro Molecular Chemistry and Physics. Figure 1: A) Synthetic scheme of polymer-conjugated Hbs. D) SEC profiles and E) CD spectra of polymer6-Hbs ([Hb] = 2 µm, in PBS). Figure 2: A) O2 dissociation curves of polymerm-Hbs at 37 °C (in PBS, pH 7.4). B) O2 dissociation curves of a mixture of PEtOx6-Hb and PEtOx6-HbT at 37 °C (in PBS, pH 7.4). Figure 4: Viscosities of polymer6-Hbs ([Hb] = 5 g dL−1 in PBS, pH 7.4, 37 °C) at 230 s−1
December 17, 2024 at 9:34 AM
michellejansman.bsky.social
New research on HBOCs from the Bäumler group (Charité-Universitätsmedizin, DE) 🧪
doi.org/10.3390/anti...

Interesting findings:
* CAT-HbMP has increased oxyHb content
* CAT-SOD combination best for protective effect
* Controlled Vit C conc (Vit C : Hb = 1:25) gives antioxidant protection
Article: Hemoglobin in Submicron Particles (HbMPs) Is Stabilized Against Oxidation, published in Antioxidants. Rerkshanandana et al. Figure 1. Schematic of the fabrication of Hb submicron particles (HbMPs) containing enzymes (CAT, SOD) through a Co-precipitation-Crosslinking-Dissolution technique. Table 1. Hydrodynamic size, PDI, and zeta potential of all HbMP types. Figure 2. Relative oxygenated Hb (Oxy-Hb) concentration of all HbMP types. Figure 8. Relative functional Hb levels of all HbMP types before and after 10X cyclic oxy/deoxygenation procedures, with and without Vit. C. #TissueEngineering, oxygen carriers, blood substitutes
December 12, 2024 at 2:53 PM
michellejansman.bsky.social
Take home message. Human organ chips are more than potential animal replacements. they are also mechanistic drug discovery tools that: 1) can provide new insight into human pathophysiology, 2) can be combined with advanced analytical approaches, 3) enable rapid drug repurposing, 4) accelerate discovery of novel therapeutics, 5) also, potentially can short cut clinical trials design by defining human PK parameters on-chip
December 10, 2024 at 2:44 PM
michellejansman.bsky.social
A previously unknown cellular behavior called ‘cell tumbling’ is reported by Yang et al. @Stanford.
Characterized by minute-scale whole-cell movements and rapid hydrogel deformation. Elicited by heightened cytoskeletal and nuclear dynamics.

doi.org/10.1038/s415...

#TissueEngineering 🧪
1/2
December 5, 2024 at 12:07 PM
michellejansman.bsky.social
New paper by Palmer et al. (Ohio State U), one of the big groups working on blood substitutes. Worth following their progress! 🧪
The pilot-scale production of T- and R-state PolyhHb allows for large-scale development and modulation of their p50.
doi.org/10.1021/acs....
#HBOCs #ChemSky #AcademicSky
Paper: Scalable production and biophysical characterization of high-molecular-weight relaxed and tense quartenary state polymerized human hemoglobin as potential red blood cell substitutes, published in BioMacroMolecules. Table 1 (partially) shows the biophysical properties of the hHb and polyhHb’s tested in this study itself. Figure 3A) the oxygen equilibrium curves and Figure 5A) the auto-oxidation kinetics of the hHb, T-state, and R-state polyhHb’s
November 28, 2024 at 9:10 AM
michellejansman.bsky.social
doi.org/10.1002/ppsc...
Paper: Optimization and investigation of hemoglobin-loaded ZIF-90 metal-organic framework nanoparticles as artificial oxygen carriers, published in particle & particle system characterization. Scheme 1 showing the synthesis of the Hb@ZIF-90 NPs. Figure 5: Effect of the incorporation of different concentrations of Hb. a) Photographic images of Hb@ZIF-90 NPs. b) Yield, c) Hb concentration, d) encapsulation efficiency (EE), e) drug loading (DL) . Figure 7: Effect of the incorporation of different concentrations PEG and PVP. a) Photographic images. b) Yield, c) Hb concentration, d) encapsulation efficiency (EE), e) drug loading (DL)
November 21, 2024 at 11:17 AM
michellejansman.bsky.social
Interesting read 🧪:
Spectroscopic characterization of Hb in presence of TATF-COF
+ TATF-COF has regular spherical morphology (2-5 µm)
- Usage of lyophilized Hb (metHb)
+ Only slight alteration to Hb structure upon conjugation

doi.org/10.1016/j.sa...

#HBOCs #ChemSky #AcademicSky
Paper: Spectroscopic characterization of triazine based covalent organic framework (COF) tempted changes in structure of hemoglobin (Hb). Scheme 1: schematic of the synthesis of TATF-COF. Figure 3: CD spectra of Hb in the presence of different concentrations of TATF-COF, in far (c) and near (d) UV regions. Figure 4D: TEM for conjugate of Hb with 0.03 mg/mL TATF-COF. Figure 5A: hydrodynamic size of Hb in presence of different concentrations of TATF-COF.
November 18, 2024 at 2:31 PM
michellejansman.bsky.social
Happy to share this new paper from Leticia Hosta-Rigau's lab @DTU_HealthTech. It is the first in vivo investigation of HBOCs published in my old group. Looking forward to see more of this!

doi.org/10.1016/j.bi...

#PaperAlert #ChemSky #AcademicSky🧪👩‍🔬
Paper: In vitro and in vivo investigations of hemoglobin-loaded PEGylated ZIF-8 nanoparticles as oxygen carriers for emergency transfusion, published in Biomaterials Advances. Figure 2 A) Showing the SEM images of the NPs. Figure 9 B) shows a table of the pharmacokinetic parameters after intravenous administration. Figure 10 shows the biodistribution of the NPs in the vital organs (liver, kidney, brain, heart, lungs, spleen, and intestines) after intravenous injection.
November 18, 2024 at 10:22 AM
michellejansman.bsky.social
My synthesis is not synthes-ing today, so hereby a throwback to a synthesis that did work out 🧪👩‍🔬

I have used these CeO2-nanoparticles both for ROS scavenging and NO releasing purposes.
doi.org/10.1021/acsa...
doi.org/10.1016/j.co...

#ChemSky #AcademicSky #QueerInSTEM #Nanozymes #HBOCs
November 12, 2024 at 12:40 PM