Wow this is so cool! Thank you so much for highlighting our work!!!

The snRNA-seq turns up some interesting candidate genes that could mediate extinction-induced suppression of fear cells, e.g.:

Next, we used snRNA-seq to show that extinction training markedly changes transcription patterns in DG granule cells that encode a fear memory, and that cells activated during recall of fear and recall of extinction have distinct transcriptomic profiles.

We confirm that extinction suppresses reactivation of fear engram cells in dorsal and ventral dentate gyrus. We find that this suppression also occurs in dorsal CA1 but --interestingly-- not in ventral CA1. Perhaps vCA1 maintains a fear representation that is resistant to extinction?

I’m so sad it’s over. That journal taxonomy was one of the funniest things I’ve ever read