Does it protect against playoff losses? Go dodgers!

One detail we are very excited about: the potential for PCIPs to selectively target tumors with acquired resistance to conventional PARP inhibitors. while KO of PARP1 is a major mechanism of resistance to PARPi, PARP1 knockout cells are actually more sensitive to PCIP-1. (3/3)

Thanks to @durocher1.bsky.social & all collaborators. Highlights: a generalizable strategy to discover new classes of CIPs, synthetic lethality with BRCA mutations, overcoming resistance to conventional PARP inhibitors, and proof-of-concept for rewiring DNA repair with proximity pharmacology. (2/3)

Yesterday’s game rocked

At his last celebration, he said something that stayed with me: "When you start, you think science is about the papers...then you realize it's about the people."

several of which bat at the top of the order in semester II of Chem Bio here at TSRI

such exciting news! congrats georg!

Time stamped right before the USA domination! 😂

I get that. Obviously I, like Ryan, am at the type of institute that would be among the most severely affected. But I would still like to see good science to get good airtime.

I’m becoming quite good at magical thinking