@mghsteelelabs.bsky.social
Publication Alert @natureportfolio.nature.com 🚨 - Organ-specific breast cancer metastasis reflects complex nutrient–tumor interactions, not single metabolites. Purine synthesis is a conserved vulnerability. rdcu.be/eX1L7
Nutrient requirements of organ-specific metastasis in breast cancer
Nature - How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.
rdcu.be
January 7, 2026 at 5:37 PM
Publication Alert @natureportfolio.nature.com 🚨 - Organ-specific breast cancer metastasis reflects complex nutrient–tumor interactions, not single metabolites. Purine synthesis is a conserved vulnerability. rdcu.be/eX1L7
🚨 New from our lab in @PNASNews: We developed a physiologically based model to optimize CAR-T therapy in solid tumors. Vascular normalization can cut CAR-T doses 5x & boost efficacy in tough tumors like glioblastoma & PDAC. www.pnas.org/doi/10.1073/... @mgbresearch.bsky.social
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 12, 2025 at 5:05 PM
🚨 New from our lab in @PNASNews: We developed a physiologically based model to optimize CAR-T therapy in solid tumors. Vascular normalization can cut CAR-T doses 5x & boost efficacy in tough tumors like glioblastoma & PDAC. www.pnas.org/doi/10.1073/... @mgbresearch.bsky.social
Excited to share our recent discovery on combination therapy strategies to overcome treatment resistance in glioblastoma, now highlighted by
@MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
@MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
Research Spotlight: Combination Therapy Shows Promise for Overcoming Treatment Resistance in Glioblastoma | Mass General Brigham
Glioblastoma (GBM) is a deadly brain cancer. Current treatments, including a type of immunotherapy called anti-PD1, don’t work well for most patients. New research has identified a promising new treat...
www.massgeneralbrigham.org
September 17, 2025 at 4:40 PM
Excited to share our recent discovery on combination therapy strategies to overcome treatment resistance in glioblastoma, now highlighted by
@MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
@MassGeneralNew @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
Publication alert 🚨 Mutant p53 hijacks enhancers to drive CXCL1 expression and create an immunosuppressive TME in #PDAC. Targeting these enhancer-chemokine circuits could boost immunotherapy in PDAC. t.co/K84OB4NlOx #MGHCancerCenter #kochinstitute @harvardmed.bsky.social
June 30, 2025 at 6:54 PM
Publication alert 🚨 Mutant p53 hijacks enhancers to drive CXCL1 expression and create an immunosuppressive TME in #PDAC. Targeting these enhancer-chemokine circuits could boost immunotherapy in PDAC. t.co/K84OB4NlOx #MGHCancerCenter #kochinstitute @harvardmed.bsky.social
Honored to see our Director, Dr. Rakesh Jain, recognized for his pioneering work in intravital microscopy and the tumor microenvironment. A true visionary in cancer research!
#AACR25 #TME #IntravitalMicroscopy
#AACR25 #TME #IntravitalMicroscopy
We caught up with the @theaacr.bsky.social Award for Lifetime Achievement in Cancer Research winner, Rakesh Jain (@harvardmed.bsky.social) to discuss his pioneering work in the tumor microenvironment and invention of the intravital microscopy imaging method.
www.biotechniques.com/cancer-resea...
www.biotechniques.com/cancer-resea...
A window to cancer’s soul: the creation of intravital microscopy and the rise of the TME
We discuss the tumor microenvironment and intravital microscopy with its inventor Rakesh Jain, a pioneer of the TME.
www.biotechniques.com
June 17, 2025 at 8:10 PM
Honored to see our Director, Dr. Rakesh Jain, recognized for his pioneering work in intravital microscopy and the tumor microenvironment. A true visionary in cancer research!
#AACR25 #TME #IntravitalMicroscopy
#AACR25 #TME #IntravitalMicroscopy
Reposted
We caught up with the @theaacr.bsky.social Award for Lifetime Achievement in Cancer Research winner, Rakesh Jain (@harvardmed.bsky.social) to discuss his pioneering work in the tumor microenvironment and invention of the intravital microscopy imaging method.
www.biotechniques.com/cancer-resea...
www.biotechniques.com/cancer-resea...
A window to cancer’s soul: the creation of intravital microscopy and the rise of the TME
We discuss the tumor microenvironment and intravital microscopy with its inventor Rakesh Jain, a pioneer of the TME.
www.biotechniques.com
June 17, 2025 at 5:54 PM
We caught up with the @theaacr.bsky.social Award for Lifetime Achievement in Cancer Research winner, Rakesh Jain (@harvardmed.bsky.social) to discuss his pioneering work in the tumor microenvironment and invention of the intravital microscopy imaging method.
www.biotechniques.com/cancer-resea...
www.biotechniques.com/cancer-resea...
New publication Alert! We developed a mathematical model to decipher how the gut microbiome shapes cancer immunotherapy response. Key insight: Microbiome composition influences immune cell activation & killing rates—critical for tumor control. @harvard.edu @mghsteelelabs.bsky.social
Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy
Abstract. The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome influences immunot...
aacrjournals.org
May 29, 2025 at 2:56 PM
New publication Alert! We developed a mathematical model to decipher how the gut microbiome shapes cancer immunotherapy response. Key insight: Microbiome composition influences immune cell activation & killing rates—critical for tumor control. @harvard.edu @mghsteelelabs.bsky.social
We review how mathematical modeling and AI can be combined to improve delivery & efficacy of molecular, nano, antibody & cellular therapies in solid tumors. www.nature.com/articles/s41... #TME #AIinOncology #CancerResearch @harvard.edu
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer - Nature Reviews Cancer
Here Harkos et al. review the role of continuous models and discrete models in predicting and understanding therapy delivery and efficacy in solid tumours. They propose ways to integrate mechanistic a...
www.nature.com
May 27, 2025 at 2:25 PM
We review how mathematical modeling and AI can be combined to improve delivery & efficacy of molecular, nano, antibody & cellular therapies in solid tumors. www.nature.com/articles/s41... #TME #AIinOncology #CancerResearch @harvard.edu
Dr. Rakesh Jain of @mghsteelelabs.bsky.social shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy today.
#AACR2025 @harvard.edu
#AACR2025 @harvard.edu
Ludwig @harvard.edu’s Rakesh Jain, recipient of the #AACR2025 Award for Lifetime Achievement in Cancer Research, told the tale of his 4-decade journey from proposing the vascular normalization hypothesis to seeing it applied today to treat multiple cancers. bit.ly/3Egq1bv
May 19, 2025 at 4:19 PM
Dr. Rakesh Jain of @mghsteelelabs.bsky.social shared insights from his decades-long work on vascular normalization—from concept to clinic. His lecture emphasized strategies to improve tumor vessel function and how these principles are transforming cancer therapy today.
#AACR2025 @harvard.edu
#AACR2025 @harvard.edu