Matthias Fellner
@mfellnerlab.bsky.social
Understand protein structure-function relationships and use this knowledge to answer fundamental questions of chemistry/biochemistry at the University of Otago.
Check out our latest review on digestion-resistant proteins, a collaboration with the Zhang lab (China Agricultural University) and Otago @otagobiochemist.bsky.social / Food Sciences. doi.org/10.1080/1040...
Dual mechanisms of digestion-resistant proteins in food systems: structural resistance and enzyme inhibition
Digestion-resistant proteins, which are proteins that reduce or inhibit the digestive process of dietary nutrients, might be an emerging field to explore. Growing public interest in food compositio...
doi.org
September 7, 2025 at 9:53 PM
Check out our latest review on digestion-resistant proteins, a collaboration with the Zhang lab (China Agricultural University) and Otago @otagobiochemist.bsky.social / Food Sciences. doi.org/10.1080/1040...
Reposted by Matthias Fellner
Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation - Nature Communications
Staphylococcus aureus is a leading cause of bacteria-associated mortality worldwide. New tools are needed to both image and treat this pathogen. We previously identified a group of S. aureus serine hy...
link.springer.com
May 30, 2025 at 9:55 PM
Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
May 13, 2025 at 7:38 AM
Great collaboration with Suzanne Warring, Hazel Sisson @peterfineran.bsky.social and others to combat kiwifruit canker via an endolysin-lipase chimera, grateful to be involved, check it out here: www.jbc.org/article/S002...
Reposted by Matthias Fellner
Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display
Peptide macrocycles are promising therapeutics for a variety of disease indications due to their overall metabolic stability and potential to make highly selective binding interactions with targets. R...
pubs.acs.org
February 25, 2025 at 2:51 AM
Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
Reposted by Matthias Fellner
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
Activity-Based Protein Profiling Identifies an α-Amylase Family Protein Contributing to the Virulence of Methicillin-Resistant Staphylococcus aureus
In search of new putative antimicrobial drug targets in methicillin-resistant Staphylococcus aureus, we aimed to identify and characterize retaining glycosidase activities in this bacterial pathogen. ...
pubs.acs.org
February 11, 2025 at 8:38 AM
New article out in ACS Infectious Diseases! Using activity-based probes by H. Overkleeft, former PhD candidate @jalal228.bsky.social identified an alpha-amylase family protein of S. aureus supporting virulence during Galleria infection! @monaj66.bsky.social pubs.acs.org/doi/10.1021/...
Happy to share our paper "Similar but Distinct—Biochemical Characterization of the Staphylococcus aureus Serine Hydrolases FphH and FphI" in PROTEINS doi.org/10.1002/prot... - cryo vs room temperature protein crystallography, SAXS, molecular dynamics and much more to uncover key enzyme differences.
December 29, 2024 at 11:09 PM
Happy to share our paper "Similar but Distinct—Biochemical Characterization of the Staphylococcus aureus Serine Hydrolases FphH and FphI" in PROTEINS doi.org/10.1002/prot... - cryo vs room temperature protein crystallography, SAXS, molecular dynamics and much more to uncover key enzyme differences.
Just out Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus: doi.org/10.1016/j.ab... MS & NMR to dig into lipid differences between strains, living states & media. Get in contact to investigate your lipids of interest together!
December 13, 2024 at 10:43 AM
Just out Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus: doi.org/10.1016/j.ab... MS & NMR to dig into lipid differences between strains, living states & media. Get in contact to investigate your lipids of interest together!