Thierry T. Schmidlin
@metabomainz.bsky.social
Junior Professor for MS-based metabolomics @UniMainz
Interested/experienced in clinical metabolomics, LC-MS method development, high-throughput analyses and metabolite antigen presentation
Interested/experienced in clinical metabolomics, LC-MS method development, high-throughput analyses and metabolite antigen presentation
🚨Paper alert🚨
In a recently published paper, we investigated metabolite ex vivo stability in the context of autoimmunity and medication exposure. Check out the news item on our website for more information and paper link 🙂
#metabolomics
#teammassspec
www.unimedizin-mainz.de/immunologie/...
In a recently published paper, we investigated metabolite ex vivo stability in the context of autoimmunity and medication exposure. Check out the news item on our website for more information and paper link 🙂
#metabolomics
#teammassspec
www.unimedizin-mainz.de/immunologie/...
Neue Erkenntnisse zur metabolischen Probenstabilität bei Autoimmunerkrankungen
Forschende der Universitätsmedizin Mainz zeigen, dass Krankheit und Medikamente die Stabilität von Metaboliten schon vor der Analyse verändern
www.unimedizin-mainz.de
November 17, 2025 at 12:38 PM
🚨Paper alert🚨
In a recently published paper, we investigated metabolite ex vivo stability in the context of autoimmunity and medication exposure. Check out the news item on our website for more information and paper link 🙂
#metabolomics
#teammassspec
www.unimedizin-mainz.de/immunologie/...
In a recently published paper, we investigated metabolite ex vivo stability in the context of autoimmunity and medication exposure. Check out the news item on our website for more information and paper link 🙂
#metabolomics
#teammassspec
www.unimedizin-mainz.de/immunologie/...
🚨Preprint altert!🚨
Check out the newest preprint coming out of our collaboration with the Weinmann-Menke lab, describing effects of disease and medication on pre-analytical stability in metabolomics in the context of Lupus:
doi.org/10.26434/che...
Check out the newest preprint coming out of our collaboration with the Weinmann-Menke lab, describing effects of disease and medication on pre-analytical stability in metabolomics in the context of Lupus:
doi.org/10.26434/che...
Disease and Medication Context Shape ex vivo Metabolite Stability: A Pilot Study in Systemic Lupus Erythematosus
Pre-analytical variation is a major challenge in metabolomics, yet most stability studies have focused on healthy volunteers and overlooked the impact of disease and medication. To address this gap, w...
doi.org
September 12, 2025 at 4:53 PM
🚨Preprint altert!🚨
Check out the newest preprint coming out of our collaboration with the Weinmann-Menke lab, describing effects of disease and medication on pre-analytical stability in metabolomics in the context of Lupus:
doi.org/10.26434/che...
Check out the newest preprint coming out of our collaboration with the Weinmann-Menke lab, describing effects of disease and medication on pre-analytical stability in metabolomics in the context of Lupus:
doi.org/10.26434/che...
🚨Publication alert - out today!🚨
Have you ever wondered if you could do #metabolite #antigen #discovery by chemically #crosslinking the antigen to the antigen presenting molecule #MR1?
We did!
And it works a treat - check out our new methodology :)
#teammassspec
www.cell.com/cell-reports...
Have you ever wondered if you could do #metabolite #antigen #discovery by chemically #crosslinking the antigen to the antigen presenting molecule #MR1?
We did!
And it works a treat - check out our new methodology :)
#teammassspec
www.cell.com/cell-reports...
MR1-ligand cross-linking identifies vitamin B6 metabolites as TCR-reactive antigens
Schmidlin et al. present a method for the discovery of metabolite antigens presented
by major histocompatibility complex class I-related protein (MR1) by chemical cross-linking
and subsequent mass spe...
www.cell.com
August 4, 2025 at 4:35 PM
🚨Publication alert - out today!🚨
Have you ever wondered if you could do #metabolite #antigen #discovery by chemically #crosslinking the antigen to the antigen presenting molecule #MR1?
We did!
And it works a treat - check out our new methodology :)
#teammassspec
www.cell.com/cell-reports...
Have you ever wondered if you could do #metabolite #antigen #discovery by chemically #crosslinking the antigen to the antigen presenting molecule #MR1?
We did!
And it works a treat - check out our new methodology :)
#teammassspec
www.cell.com/cell-reports...
Check out the great work led by our colleagues Georg Bündgen and Tobi Bopp investigating how tumor-secreted polyamines shape the phenotype of regulatory T cells
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
Redirecting
doi.org
August 1, 2025 at 6:49 AM
Check out the great work led by our colleagues Georg Bündgen and Tobi Bopp investigating how tumor-secreted polyamines shape the phenotype of regulatory T cells
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
Great tool for multi-omics intregration developped and published by our collaborators in the group of Miguel Andrade-Navarro. 🥳
www.mdpi.com/2218-273X/15...
www.mdpi.com/2218-273X/15...
www.mdpi.com
March 26, 2025 at 9:50 AM
Great tool for multi-omics intregration developped and published by our collaborators in the group of Miguel Andrade-Navarro. 🥳
www.mdpi.com/2218-273X/15...
www.mdpi.com/2218-273X/15...
DIASyM Guest Talk Announcement:
29 January, 3PM CET:
Biomarker Discovery with Biologically Informed Neural Networks
Talk by Dr. D.A. Selby,
Hosted by T. Hauptmann.
Open to anyone interested.
Link for online attendance to be found under the link provided:
diasym.mscoresys.de/de/news/scie...
29 January, 3PM CET:
Biomarker Discovery with Biologically Informed Neural Networks
Talk by Dr. D.A. Selby,
Hosted by T. Hauptmann.
Open to anyone interested.
Link for online attendance to be found under the link provided:
diasym.mscoresys.de/de/news/scie...
Scienetific Talk | DIASyM
diasym.mscoresys.de
January 23, 2025 at 12:40 PM
DIASyM Guest Talk Announcement:
29 January, 3PM CET:
Biomarker Discovery with Biologically Informed Neural Networks
Talk by Dr. D.A. Selby,
Hosted by T. Hauptmann.
Open to anyone interested.
Link for online attendance to be found under the link provided:
diasym.mscoresys.de/de/news/scie...
29 January, 3PM CET:
Biomarker Discovery with Biologically Informed Neural Networks
Talk by Dr. D.A. Selby,
Hosted by T. Hauptmann.
Open to anyone interested.
Link for online attendance to be found under the link provided:
diasym.mscoresys.de/de/news/scie...
Nice work by our collaborators in Cardiff. Looking forward to joint follow-up projects across our two labs...
A follow up study to the Nature Immunology paper we published on the MR1-restricted T-cells (MC.7.G5) that respond to cancer! This time, cancer specific recognition of cancer cell lines through the use of a semi-invariant TCR containing a TRAJ42 segment and a CAXYGGSQGNLIF TCRα motif.
JCI -
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
www.jci.org
January 3, 2025 at 10:27 AM
Nice work by our collaborators in Cardiff. Looking forward to joint follow-up projects across our two labs...
November 19, 2024 at 5:44 PM