4) “the complexity of biological phenomena is an argument for the use of mathematical methods rather than against it. In the case of a simple phenomenon we may hope to understand it without the use of mathematics, by simple inspection. But in a complex case we are left hopeless without mathematics.”

Very cool, will try it out!! :)

Lol 😆

Awesome, congrats!!!

(The first concept TopoTome version is now on biorxiv, linked below; stay tuned for the big guns - TopoTome v2)

www.biorxiv.org/content/10.1...

The paper itself (with Henry Potter) is here: onlinelibrary.wiley.com/doi/10.1111/... (and is the European Journal of Neuroscience's most downloaded paper over the last two years! 😊)

Excellent opinion paper, I really enjoyed reading it, especially since it very much resonates with how my lab has been thinking about the brain and mechanistic causes and emergence of individual behavior, resolved by time. Congratulations!

The larger problem is the textbooks frame things in a "X does Y" kind of way. It's very hard to get people to envision a dynamic, reverberant, reciprocally interconnected system and what that will mean for where signals of different types can be observed...I don't have a good answer for this...

Good luck with this one, lol

No, thank you! Stay strong, we’ll weather this hopefully short storm being a tight community that we are. 💪🏻

I mean, generally the place was actually really great and there were many people vibing with what I proposed to get to interview, but that one conversation really stuck with me :p

A (not exact) wording was: “you know, today in neuroscience if you can’t get to the neuron level, it will be very difficult to find a way to get it published“