Melody Di Bona
@melodydibona.bsky.social
Cancer cell biologist | microscopist. MS-Biotechnology| PhD-Physics 🔬Postdoc@BakhoumLab,MSK. Mitochondrial ROS | micronuclei | nanoscopy. On the academic job market| viewsAreMyOwn
Mitochondria transform micronuclei in time bombs propelling cancer cells towards distant metastasis and therapy resistance!💣⏱️
But....
What is the evolutionary purpose of this mechanism? What makes micronuclei different from the primary nucleus? 🤔
Stay tuned to know more! 🙃
But....
What is the evolutionary purpose of this mechanism? What makes micronuclei different from the primary nucleus? 🤔
Stay tuned to know more! 🙃
November 21, 2024 at 12:01 AM
Mitochondria transform micronuclei in time bombs propelling cancer cells towards distant metastasis and therapy resistance!💣⏱️
But....
What is the evolutionary purpose of this mechanism? What makes micronuclei different from the primary nucleus? 🤔
Stay tuned to know more! 🙃
But....
What is the evolutionary purpose of this mechanism? What makes micronuclei different from the primary nucleus? 🤔
Stay tuned to know more! 🙃
We discovered that micronuclei rupture because of proximity to mitochondria! Mitochondria leak Reactive Oxygen Species that alter nuclear export and protein oligomerization. ROS rupture micronuclei, and also inhibit their repair! (2/3)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Micronuclear collapse from oxidative damage
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture cat...
www.science.org
November 21, 2024 at 12:01 AM
We discovered that micronuclei rupture because of proximity to mitochondria! Mitochondria leak Reactive Oxygen Species that alter nuclear export and protein oligomerization. ROS rupture micronuclei, and also inhibit their repair! (2/3)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...