Mohamed Elghazaly
@melghazaly.bsky.social
Research Fellow in Towers Lab at UCL working on HIV and innate immunity.
Former Postdoctoral Research Associate in Humphreys Lab at University of Sheffield where I worked on bacterial toxin-induced senescence.
Former Postdoctoral Research Associate in Humphreys Lab at University of Sheffield where I worked on bacterial toxin-induced senescence.
Reposted by Mohamed Elghazaly
Our first Virtual Virology at QMUL! Three great speakers from my lab @melghazaly.bsky.social on Vpx and immune activation, @immun0liver.bsky.social on SARS and ADP-ribosylation, and @ali-hashim.bsky.social on transforming natural products into broad spectrum anti-virals. Excited for the next VV!
November 14, 2025 at 12:29 PM
Our first Virtual Virology at QMUL! Three great speakers from my lab @melghazaly.bsky.social on Vpx and immune activation, @immun0liver.bsky.social on SARS and ADP-ribosylation, and @ali-hashim.bsky.social on transforming natural products into broad spectrum anti-virals. Excited for the next VV!
Excited to share that the Towers Lab have moved from UCL to the @blizardinstitute.bsky.social. As such, I’ll be continuing working on #virology and #epigenetic regulation of #immunity from the Blizard! I look forward to meet new colleagues and continue working on great science. Get in touch!
October 6, 2025 at 1:57 PM
Excited to share that the Towers Lab have moved from UCL to the @blizardinstitute.bsky.social. As such, I’ll be continuing working on #virology and #epigenetic regulation of #immunity from the Blizard! I look forward to meet new colleagues and continue working on great science. Get in touch!
Reposted by Mohamed Elghazaly
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...
www.biorxiv.org
September 29, 2025 at 3:38 PM
New preprint from our lab, led by our postdocs Dara Annett and Kate Morling in collaboration with Selwood Lab!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
We developed a modified cyclosporine, BG147, which enhances lentivector gene therapy transduction, ex vivo in HSPC and in vivo in mouse photoreceptors, by degrading IFITM3. Check it out!
Reposted by Mohamed Elghazaly
Delighted to have won a Wellcome Discovery Award for 8 more years of transformative research. We will advance our knowledge of innate immune mechanisms using viruses and chemotherapeutics as tools.
Thanks to everyone who contributed along the way.
Thanks to everyone who contributed along the way.
September 29, 2025 at 2:40 PM
Delighted to have won a Wellcome Discovery Award for 8 more years of transformative research. We will advance our knowledge of innate immune mechanisms using viruses and chemotherapeutics as tools.
Thanks to everyone who contributed along the way.
Thanks to everyone who contributed along the way.
Reposted by Mohamed Elghazaly
We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations.
www.qmul.ac.uk/blizard/abou...
www.qmul.ac.uk/blizard/abou...
Blizard Institute welcomes world-leading team of virologists
www.qmul.ac.uk
July 10, 2025 at 1:05 PM
We are delighted to be joining the Blizard Institute in Autumn. The Blizard Institute is an amazing place for discovery science and we're looking forward to more transformative research and collaborations.
www.qmul.ac.uk/blizard/abou...
www.qmul.ac.uk/blizard/abou...
Reposted by Mohamed Elghazaly
Virtual Virology 2 July - Three Pirbright PIs. Do join us
June 20, 2025 at 11:23 AM
Virtual Virology 2 July - Three Pirbright PIs. Do join us
Reposted by Mohamed Elghazaly
Our last (but not least) selected speaker for today is @immun0liver.bsky.social @ucl.ac.uk with a great talk on how ADP-ribosylation poses an important barrier to infection that viruses like SARS-CoV-2 have to overcome. #LINEsymposium2025
June 9, 2025 at 2:30 PM
Our last (but not least) selected speaker for today is @immun0liver.bsky.social @ucl.ac.uk with a great talk on how ADP-ribosylation poses an important barrier to infection that viruses like SARS-CoV-2 have to overcome. #LINEsymposium2025
Towers Lab attending @londoninfectionecr.bsky.social (LINE) annual symposium. Great talk lineups at the Francis Crick Institute, London. #LINE #ScienceIsCool.
June 9, 2025 at 12:42 PM
Towers Lab attending @londoninfectionecr.bsky.social (LINE) annual symposium. Great talk lineups at the Francis Crick Institute, London. #LINE #ScienceIsCool.
What an absolute privilege it was to be invited to speak at #UKCellularMicrobiology @KingsCollegeLon!
Having attended this conference for years as a Salmonella biologist, it was really special to come back this time as a Virologist. #AcademicLife #CellularMicrobiology #Research
Having attended this conference for years as a Salmonella biologist, it was really special to come back this time as a Virologist. #AcademicLife #CellularMicrobiology #Research
June 4, 2025 at 5:20 PM
What an absolute privilege it was to be invited to speak at #UKCellularMicrobiology @KingsCollegeLon!
Having attended this conference for years as a Salmonella biologist, it was really special to come back this time as a Virologist. #AcademicLife #CellularMicrobiology #Research
Having attended this conference for years as a Salmonella biologist, it was really special to come back this time as a Virologist. #AcademicLife #CellularMicrobiology #Research
Reposted by Mohamed Elghazaly
May 23, 2025 at 4:16 PM
I had the great honour of being invited to speak at the Cold Spring Harbor Retroviruses Meeting in New York last week!
#CSHRetroviruses #Retrovirology #Research
#CSHRetroviruses #Retrovirology #Research
May 30, 2025 at 5:47 PM
I had the great honour of being invited to speak at the Cold Spring Harbor Retroviruses Meeting in New York last week!
#CSHRetroviruses #Retrovirology #Research
#CSHRetroviruses #Retrovirology #Research
So inspiring just listening to a keynote lecture at Cold Spring Harbor by David Baltimore, a Nobel Prize Winner at the age of 37, and the discoverer of reverse transcriptase that quite literally changed the world. #CSHLRetro
May 21, 2025 at 12:29 AM
So inspiring just listening to a keynote lecture at Cold Spring Harbor by David Baltimore, a Nobel Prize Winner at the age of 37, and the discoverer of reverse transcriptase that quite literally changed the world. #CSHLRetro
Reposted by Mohamed Elghazaly
Virtual Virology is back - our first ever phage session. Do join us...
May 8, 2025 at 6:09 PM
Virtual Virology is back - our first ever phage session. Do join us...
Reposted by Mohamed Elghazaly
Thanks to everybody who made it to our seminar yesterday (IRL and remotely)! It was great to hear about their exciting science from @oscart32.bsky.social and @melghazaly.bsky.social. See you very soon at our symposium or the next seminar!
April 10, 2025 at 4:17 PM
Thanks to everybody who made it to our seminar yesterday (IRL and remotely)! It was great to hear about their exciting science from @oscart32.bsky.social and @melghazaly.bsky.social. See you very soon at our symposium or the next seminar!
Reposted by Mohamed Elghazaly
Come next Wednesday at 5pm at #UCL to listen to @oscart32.bsky.social and @melghazaly.bsky.social share their science and have a drink with us after!
The event is hybrid to cater for availability and capacity, so if you cannot make it in person, join us online!
The event is hybrid to cater for availability and capacity, so if you cannot make it in person, join us online!
🚨INCOMING! Join us for our next LINE seminar (9th of April) at UCL. We are excited to host @oscart32.bsky.social and @melghazaly.bsky.social to hear about metagenomics in diagnostics and how host/pathogens battle it out! As always: Followed by a networking social! Register here: shorturl.at/kGmfh
April 2, 2025 at 4:03 PM
Come next Wednesday at 5pm at #UCL to listen to @oscart32.bsky.social and @melghazaly.bsky.social share their science and have a drink with us after!
The event is hybrid to cater for availability and capacity, so if you cannot make it in person, join us online!
The event is hybrid to cater for availability and capacity, so if you cannot make it in person, join us online!
Reposted by Mohamed Elghazaly
🚨INCOMING! Join us for our next LINE seminar (9th of April) at UCL. We are excited to host @oscart32.bsky.social and @melghazaly.bsky.social to hear about metagenomics in diagnostics and how host/pathogens battle it out! As always: Followed by a networking social! Register here: shorturl.at/kGmfh
March 11, 2025 at 5:12 PM
🚨INCOMING! Join us for our next LINE seminar (9th of April) at UCL. We are excited to host @oscart32.bsky.social and @melghazaly.bsky.social to hear about metagenomics in diagnostics and how host/pathogens battle it out! As always: Followed by a networking social! Register here: shorturl.at/kGmfh
Reposted by Mohamed Elghazaly
Happy to announce that our 2nd paper of 2025 is out! 🎊
This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.
www.nature.com/articles/s41...
This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.
www.nature.com/articles/s41...
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV - Nature Communications
Targeted protein degradation has so far been rarely applied as an antiviral strategy. Here, the authors report that macrocycle-based PROTACs targeting host protein cyclophilin A, exploited during vira...
www.nature.com
February 14, 2025 at 12:53 PM
Happy to announce that our 2nd paper of 2025 is out! 🎊
This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.
www.nature.com/articles/s41...
This collaboration between our brilliant postdoc @lsnewton.bsky.social and @claragathmann.bsky.social, from Dave Selwood’s chemistry lab, designs and employs PROTACs to degrade CypA and inhibit HIV and HCV.
www.nature.com/articles/s41...
Reposted by Mohamed Elghazaly
First paper of 2025 is out now! 🎉
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
January 14, 2025 at 3:30 PM
First paper of 2025 is out now! 🎉
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
Very proud to have collaborated with @katemorling.bsky.social on this review as my first contribution to the virology field. Looking forward to more exciting work with @towerslab.bsky.social!
First paper of 2025 is out now! 🎉
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
Our talented postdocs @katemorling.bsky.social and @melghazaly.bsky.social review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved (or not) to regulate host innate immunity.
www.microbiologyresearch.org/content/jour...
January 14, 2025 at 3:33 PM
Very proud to have collaborated with @katemorling.bsky.social on this review as my first contribution to the virology field. Looking forward to more exciting work with @towerslab.bsky.social!