This was indeed a fun read! Nothing makes you feel stupid as much as trying to read a paper out of your scope of knowledge

Thank you for the 🧵 ! Tagging for the #PlantScience feed!

Together with new data in RNS from our colleagues @nikolajabel.bsky.social et al. doi.org/10.1101/2025..., we hope close the gap in our understanding of the common symbiosis pathway for plant endosymbioses! 7/7

We propose that EPP1 has been a core component of AMS signaling since the origin of land plants as we know them 🌱🍄 6/7

Here we show abolition of AMS in epp1 mutants in the flowering plant Petunia and in the liverwort Marchantia. We also find that EPP1 is directly phosphorylated by the SYMRK receptor and that the epp1 phenotype can be complemented by an autoactive version of the kinase CCaMK 5/7

Knowing EPP1 belongs to the short list of genes conserved across land plants in species with the ability to form endosymbiosis and convergently lost in the ones having lost this ability, we decided switch model plants to test the function of EPP1 in Arbuscular Mycorrhiza Symbiosis (AMS). 4/7

Previously, Early Phosphorylated Protein 1 (EPP1) was suggested to play an essential role in Root Nodule Symbiosis but the high copy number of EPP1 genes in Medicago (4!) limited our ability to study its function doi.org/10.1093/pcp/... doi.org/10.1111/nph.... . 3/7

With @tatiana-vernie.bsky.social @mbianc.bsky.social @baptistebio.bsky.social @kellerjeanphd.bsky.social @malick-mbengue.bsky.social @pierremarcdelaux.bsky.social and many others 2/7

For more information: academic.oup.com/pcp/article/...
nph.onlinelibrary.wiley.com/doi/10.1111/...

Our findings suggest that EPP1 serves as a key molecular bridge between plasma membrane signaling and downstream responses doing root nodule symbiosis, helping to close a long-standing gap in the field.
Congratulations to everyone involved in this work!