Meike Wortel
@meikewortel.bsky.social
Evolutionary Systems Biologist @ SILS University of Amsterdam
https://www.meikewortel.com/
https://www.meikewortel.com/
Reposted by Meike Wortel
What, where, when?
📅 October 31st, 2025 | 12:00 – 18:00
📍 Auditorium, O2 building, Vrije Universiteit Amsterdam
🎟️ Free, register here (before 1st Oct with a talk title; 15th Oct regular): forms.office.com/e/qCrRcXhsyA
📅 October 31st, 2025 | 12:00 – 18:00
📍 Auditorium, O2 building, Vrije Universiteit Amsterdam
🎟️ Free, register here (before 1st Oct with a talk title; 15th Oct regular): forms.office.com/e/qCrRcXhsyA
Microsoft Forms
forms.office.com
September 23, 2025 at 3:50 PM
What, where, when?
📅 October 31st, 2025 | 12:00 – 18:00
📍 Auditorium, O2 building, Vrije Universiteit Amsterdam
🎟️ Free, register here (before 1st Oct with a talk title; 15th Oct regular): forms.office.com/e/qCrRcXhsyA
📅 October 31st, 2025 | 12:00 – 18:00
📍 Auditorium, O2 building, Vrije Universiteit Amsterdam
🎟️ Free, register here (before 1st Oct with a talk title; 15th Oct regular): forms.office.com/e/qCrRcXhsyA
But now we show it in very similar strains, we wonder "How does this affect evolutionary paths?". For that you have to wait for the next article! Thanks to my co-authors and the reviewers, whose reviews have made us understand our data better and really improved our article: doi.org/10.1128/mbio...
Density-dependent feedback limits the spread of beta-lactamase mutants: experimental observations and population dynamic model | mBio
Since the discovery of penicillin, β-lactam antibiotics have become the most widely
used antibiotics to treat bacterial infections. Their applicability is decreasing
because bacteria evolve resistance...
doi.org
July 26, 2025 at 12:41 PM
But now we show it in very similar strains, we wonder "How does this affect evolutionary paths?". For that you have to wait for the next article! Thanks to my co-authors and the reviewers, whose reviews have made us understand our data better and really improved our article: doi.org/10.1128/mbio...
The other nice thing is: these strains were only two mutations apart; mutations affecting the beta-lactamase TEM1. That means: costs for resistance only from TEM1 mutations are enough to sustain coexistence. For larger changes, such as with and without plasmids, coexistence was shown before.
July 26, 2025 at 12:41 PM
The other nice thing is: these strains were only two mutations apart; mutations affecting the beta-lactamase TEM1. That means: costs for resistance only from TEM1 mutations are enough to sustain coexistence. For larger changes, such as with and without plasmids, coexistence was shown before.
I very much like the part that we were able to use a population dynamic model with only measured parameters and predict quite accurately at which antibiotic concentrations and cell densities the strains would coexist! This suggests that we were capturing the most important interactions in our model.
July 26, 2025 at 12:41 PM
I very much like the part that we were able to use a population dynamic model with only measured parameters and predict quite accurately at which antibiotic concentrations and cell densities the strains would coexist! This suggests that we were capturing the most important interactions in our model.