Megan Honeywell
meghoneywell.bsky.social
Megan Honeywell
@meghoneywell.bsky.social
Haber-Maheswaran Lab postdoc @ MGH 🧫 | UMCMS Lee Lab alum
Reposted by Megan Honeywell
I’m excited to highlight our latest paper, just published in Cell 🎉

We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression.

1/n 🧪

www.cell.com/cell/fulltex...
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...
www.cell.com
August 15, 2025 at 6:35 PM