Michael Doube
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mdoube.bsky.social
Michael Doube
@mdoube.bsky.social
Pixel herder
Good bin run today! Scored a box set of the best Star Wars movies.

Waste management is a big deal in 🇨🇭. Other places have a dump or a tip but it's classy here, we have a déchetterie with maybe 20 categories to sort into. Will try to list them all in a reply...
October 6, 2025 at 4:32 PM
Long, slender trabeculae pass across the marrow space. Trabeculae help resist weightbearing loads. But these ones don't appear to be in a good configuration to do that, unlike the spongy trabeculae nearby.

Maybe they're holding adipose tissue in place, preventing it from wobbling during locomotion?
October 3, 2025 at 10:18 AM
The stripe of dense bone running from top right to lower left is the growth plate scar, separating the main part of the bone from the epiphysis, the knobbly joint condyle. It's formed when the cartilagenous growth plate stops expanding and is replaced by bone.
October 3, 2025 at 10:11 AM
Top left is the cortical ('dense') bone shell. Looks solid but it's porous, filled with millions of osteocytes and capillaries serving them. Bottom right is spongy (trabecular, cancellous) bone, thought to help spread joint loads.
October 3, 2025 at 10:06 AM
The leftovers from last week's bœuf bourguignon. This is a 'marrow bone' after boiling out the adipose tissue for gravy and washing in lots of warm tap water, household detergents and a little chlorine bleach. Cortex & (glorious) trabeculae, growth plate 'scar', marrow cavity visible.
October 3, 2025 at 10:01 AM
📢 New paper alert!

Type-I and -II collagens from bone and cartilage colocalize at the osteochondral cement line.

doi.org/10.1302/2046...

Khizar Hayat, @neilmarr.bsky.social and I show that collagens from bone and cartilage meet in a zone ~5µm thick, which might help to glue the tissues together.
August 27, 2025 at 8:33 AM
Spotted these house(boat) martins in the Finnish archipelago, nesting on a lossi (a kind of car ferry that runs a few times an hour over short distances, guided by a cable). Nice spot to spend the summer, getting free rides between islands!
July 30, 2025 at 1:44 PM
Commercial hybrid vs wild type, summer holiday edition.
July 20, 2025 at 7:29 AM
But but but they are "unbelievable at computers"! Surely that means their (de)funding decisions are sound.
May 5, 2025 at 9:57 AM
Fractures in tiny middle ear bones might underlie deafness in osteogenesis imperfecta, here in the oim mouse.

No pay wall link:
authors.elsevier.com/c/1l01CV6zM9...
May 4, 2025 at 1:54 PM
March 31, 2025 at 11:27 AM
I like spotting when buildings look like what they do inside. Biology buildings with 'spiral' staircases, because DNA is a double helix, that kind of thing.

This is the roof of the AO Center in Davos. The AO Foundation is into bone screws, and so... (see it?)
March 12, 2025 at 10:22 AM
Accepted MS!

Type-I and -II collagens from bone and cartilage colocalise at the osteochondral cement line.

The first paper from my PhD student Khizar Hayat, and the first from a grand plan to find out what attaches cartilage to bone at the nm-µm scale.

Out soon in BJR

With @neilmarr.bsky.social
February 26, 2025 at 4:04 PM
Le selfie obligatoire à la Galerie de paléontologie et d'anatomie comparée @mnhn.fr 🫶

An immense collection on display, it's a favourite of everyone, from schoolkids to the serious fossil and anatomy nerds. Also very handy to Gare de Lyon & my connection back to Geneva.
December 6, 2024 at 11:55 AM
Heading to @ethzurich.bsky.social to present at the Institute for Biomechanics colloquium, 18 Dec.

Between cols interlinked: what keeps cartilage attached to bone?

I'll be talking about what we can tell about osteochondral bonding, from images like this...
December 2, 2024 at 8:01 PM
November 24, 2024 at 9:18 PM
Poignant exhibit at the Palais de Rumine in Lausanne, not far from a taxidermied black rhino, warning of the imminent extinction of taxonomy as a discipline.
November 23, 2024 at 12:23 PM