@mchanggroup.bsky.social
Student-run account of the Michelle Chang Lab at Princeton University || Enzymology || Metabolic Engineering || Biocatalysis || Synthetic Biology
Congratulations to former student Eli and the team on their new paper in Nature Chemical Biology! Here they show that the difference in radical rebound of FeII/aKG halogenases is uniquely controlled by the switching of the metal ligand bond axes! Take a look: www.nature.com/articles/s41...
Dynamic metal coordination controls chemoselectivity in a radical halogenase - Nature Chemical Biology
Radical FeII/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.
www.nature.com
November 21, 2025 at 3:18 PM
Congratulations to former student Eli and the team on their new paper in Nature Chemical Biology! Here they show that the difference in radical rebound of FeII/aKG halogenases is uniquely controlled by the switching of the metal ligand bond axes! Take a look: www.nature.com/articles/s41...
Congrats to lead author Doug and team on their new preprint, which describes a genome mining strategy to find non-canonical amino acid-based secondary metabolites outside of RiPP and NRPS pathways! Read more below: chemrxiv.org/engage/chemr...
tRNA-Deacylase Directed Discovery of Biosynthetic Pathways
Amino acids are one of nature’s most privileged building blocks for generating molecular diversity on length-scales ranging from small molecules to proteins. While amino acid products arising from cer...
chemrxiv.org
March 23, 2025 at 10:20 PM
Congrats to lead author Doug and team on their new preprint, which describes a genome mining strategy to find non-canonical amino acid-based secondary metabolites outside of RiPP and NRPS pathways! Read more below: chemrxiv.org/engage/chemr...