And will top it off with travel to Europe/Copenhagen for a BPS thematic meeting on membrane organization in July. We are on!

This summer is going to be fun. Upcoming 3 PhD and 1 MS thesis defense. Students traveling , MBU organizing a 2-day national symposium at IISc with "AI in Biophysics" theme (updates soon), PhD admission interview week, of course drafts and reviews, etc etc.

And then yesterday, we got news of Sangeetha/Irawati's RGG-GQ (IDP-RNA) work getting accepted in Journal of Biological Chemistry!! Off we went to Glen Bake House (again on 80 ft road). With the ups and downs this paper has seen, we needed immediate gratification :-)

All heavy lifting by Vijay Subramanian, a @IISERPune BS-MS student, allowed by nice folks at Pune to do his MS thesis with me at Bangalore. Also thanks @DBTIndia (NNM) @IndiaDST
(NSM and MATRICS grants) @wellcometrust.bsky.social @India_Alliance (TSG) @iiscbangalore for the support!

We shortlisted a few candidate proteins that we will start experimental work now (putting our money where our mouth is !!). Looking forward to a very exciting collaboration with our NMR guru and my colleague, Ashok Shekar.

We ran the algorithm across 57 proteomes (we have made it fast and very high throughput using the Trie data structure for our fragment library). We claim that about 10-12% of proteins may be metamorphic.

We create and use fragment db from full repositories of PDB and AlphaFold and use entropy and other score to quantify the diversity of a peptide stretch to be in degenerate structural states. The algorithm allows us to identify the possible metamorphic region using a sliding window.