Panagiotou's lab
@mbdlab.bsky.social
Microbiome Dynamics Department at LeibnizHKI.
We study how the microbiome impacts health, diet & ecosystems.
We study how the microbiome impacts health, diet & ecosystems.
Check also the press-release: www.leibniz-hki.de/en/press-rel...
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What microbes tell us about Nonalcoholic Fatty Liver Disease
Using medical data from more than 1,200 people, specific microbiome signatures have been identified that allow pre…
www.leibniz-hki.de
January 21, 2025 at 10:12 AM
Check also the press-release: www.leibniz-hki.de/en/press-rel...
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We are incredibly grateful to the DFG (funds via @microverse.bsky.social ) and Horizon Europe (BestTreat) for supporting our project.
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January 21, 2025 at 10:12 AM
We are incredibly grateful to the DFG (funds via @microverse.bsky.social ) and Horizon Europe (BestTreat) for supporting our project.
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Congratulations to all authors, including our collaborators Weiping Jia, Aimin Xu, Bjorn Nielsen, Max Nieuwdorp, and Rohit Loomba for their great work.
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January 21, 2025 at 10:12 AM
Congratulations to all authors, including our collaborators Weiping Jia, Aimin Xu, Bjorn Nielsen, Max Nieuwdorp, and Rohit Loomba for their great work.
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Our study reveals robust and highly specific NAFLD signatures and offers a more realistic microbiome-therapeutics approach over individual species for this complex disease.
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January 21, 2025 at 10:12 AM
Our study reveals robust and highly specific NAFLD signatures and offers a more realistic microbiome-therapeutics approach over individual species for this complex disease.
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Finally, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively.
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January 21, 2025 at 10:12 AM
Finally, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively.
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We then created ML models (RF) using bacterial species and predicted metabolites to classify NAFLD-obese and controls. These models are highly accurate and specific to NAFLD compared to other metabolic diseases.
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January 21, 2025 at 10:12 AM
We then created ML models (RF) using bacterial species and predicted metabolites to classify NAFLD-obese and controls. These models are highly accurate and specific to NAFLD compared to other metabolic diseases.
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We found that NAFLD-obese and NAFLD-lean individuals have different microbiome taxonic profiles than other co-ocurring metabolic diseases. Predicted metabolites (GSMM) profiles were a priori not different between groups.
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January 21, 2025 at 10:12 AM
We found that NAFLD-obese and NAFLD-lean individuals have different microbiome taxonic profiles than other co-ocurring metabolic diseases. Predicted metabolites (GSMM) profiles were a priori not different between groups.
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In this study, we mined public data and analyze shotgun metagenomics of 1206 patients with clear information on NAFLD status and other metabolic diseases and well-characterized clinical profiles.
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January 21, 2025 at 10:12 AM
In this study, we mined public data and analyze shotgun metagenomics of 1206 patients with clear information on NAFLD status and other metabolic diseases and well-characterized clinical profiles.
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Another challenge is that studies have not considered differences between obese and lean patients (around 20% of those suffering NAFLD). Could the microbiome-signatures differ between these 2 groups?
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January 21, 2025 at 10:12 AM
Another challenge is that studies have not considered differences between obese and lean patients (around 20% of those suffering NAFLD). Could the microbiome-signatures differ between these 2 groups?
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Us and others have shown that the gut microbiome could be a powerful diagnostic tool for NAFLD. But, NAFLD can co-occur with other metabolic diseases like T2D, obesity, etc. How specific are the microbiome-signatures found in NAFLD patients?
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January 21, 2025 at 10:12 AM
Us and others have shown that the gut microbiome could be a powerful diagnostic tool for NAFLD. But, NAFLD can co-occur with other metabolic diseases like T2D, obesity, etc. How specific are the microbiome-signatures found in NAFLD patients?
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NAFLD (non-alcoholic fatty liver) has become a global epidemic, affecting around 40% of the Western world and in many cases undiagnosed until reaching severe stages
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January 21, 2025 at 10:12 AM
NAFLD (non-alcoholic fatty liver) has become a global epidemic, affecting around 40% of the Western world and in many cases undiagnosed until reaching severe stages
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In a nutshell: In a large-scale study mining public data, we identified microbiome-signatures that can differenriate between NAFLD and other commonly co-ocurring metabolic diseases. This could help in the more precise use of microbiome-based therapies for NAFLD.
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January 21, 2025 at 10:12 AM
In a nutshell: In a large-scale study mining public data, we identified microbiome-signatures that can differenriate between NAFLD and other commonly co-ocurring metabolic diseases. This could help in the more precise use of microbiome-based therapies for NAFLD.
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