Professor Sarosh Irani
@mayo-aing.bsky.social
Professor of Neurology and Neurosciences at Mayo Clinic, Florida. Ex-Oxford. Autoantibodies and Lymphocytes which affect the nervous system. Towards improved diagnosis and cure. Autoantibodies, B cells, T cells, antigen and immunotherapies
Heard it before???
It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies
ja.ma/3HkZD1y
It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies
ja.ma/3HkZD1y
A Distinctive Inspiratory Noise in IgLON5-Antibody Disease
This case series describes a distinctive inspiratory noise observed during sleep in patients with IgLON5-antibody disease.
ja.ma
June 7, 2025 at 1:06 PM
Heard it before???
It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies
ja.ma/3HkZD1y
It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies
ja.ma/3HkZD1y
academic.oup.com/brain/articl...
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
Models of autoantibody mediated diseases: actively nearing the human gold standard
Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl
academic.oup.com
June 3, 2025 at 11:02 AM
academic.oup.com/brain/articl...
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
May 30, 2025 at 10:34 AM
Reposted by Professor Sarosh Irani
Many congratulations to Professor Irani and co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.
April 30, 2025 at 2:39 PM
Many congratulations to Professor Irani and co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.
Reminder to all interested in #autoimmune #neurology
Please join us
ce.mayo.edu/neurology-and-…
For great weather, faculty talks and networking…..
This will be a small, focused meeting for you to develop your knowledge and skills i#autoimmunen#neurologygy
Please join us
ce.mayo.edu/neurology-and-…
For great weather, faculty talks and networking…..
This will be a small, focused meeting for you to develop your knowledge and skills i#autoimmunen#neurologygy
https://ce.mayo.edu/neurology-and-…
March 9, 2025 at 1:27 AM
Reminder to all interested in #autoimmune #neurology
Please join us
ce.mayo.edu/neurology-and-…
For great weather, faculty talks and networking…..
This will be a small, focused meeting for you to develop your knowledge and skills i#autoimmunen#neurologygy
Please join us
ce.mayo.edu/neurology-and-…
For great weather, faculty talks and networking…..
This will be a small, focused meeting for you to develop your knowledge and skills i#autoimmunen#neurologygy
onlinelibrary.wiley.com/doi/full/10.10…
Here is the first PROM (patient reported outcome measure) for patients wit#LGI1I1 antibod#encephalitisis
Hopefully a major inroad to measuring this disease more carefully 👍
We hope this will help patients in routine practice, and in trials
Here is the first PROM (patient reported outcome measure) for patients wit#LGI1I1 antibod#encephalitisis
Hopefully a major inroad to measuring this disease more carefully 👍
We hope this will help patients in routine practice, and in trials
https://onlinelibrary.wiley.com/doi/full/10.10…
February 28, 2025 at 11:11 PM
onlinelibrary.wiley.com/doi/full/10.10…
Here is the first PROM (patient reported outcome measure) for patients wit#LGI1I1 antibod#encephalitisis
Hopefully a major inroad to measuring this disease more carefully 👍
We hope this will help patients in routine practice, and in trials
Here is the first PROM (patient reported outcome measure) for patients wit#LGI1I1 antibod#encephalitisis
Hopefully a major inroad to measuring this disease more carefully 👍
We hope this will help patients in routine practice, and in trials
#world #encephalitis #day #america 🇺🇸 #WEDA
is today!!
On the Mayo JAX campus
@MayoClinic @MayoClinicNeuro
Kicked off by Philippa Chapman of encephalitis international
is today!!
On the Mayo JAX campus
@MayoClinic @MayoClinicNeuro
Kicked off by Philippa Chapman of encephalitis international
February 8, 2025 at 3:41 PM
#world #encephalitis #day #america 🇺🇸 #WEDA
is today!!
On the Mayo JAX campus
@MayoClinic @MayoClinicNeuro
Kicked off by Philippa Chapman of encephalitis international
is today!!
On the Mayo JAX campus
@MayoClinic @MayoClinicNeuro
Kicked off by Philippa Chapman of encephalitis international
Reposted by Professor Sarosh Irani
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️
Please sign up now ✍️
ce.mayo.edu/neurology-an...
Please sign up now ✍️
ce.mayo.edu/neurology-an...
https://ce.mayo.edu/neurology-and-…
February 3, 2025 at 12:25 PM
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️
Please sign up now ✍️
ce.mayo.edu/neurology-an...
Please sign up now ✍️
ce.mayo.edu/neurology-an...
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️
Please sign up now ✍️
ce.mayo.edu/neurology-an...
Please sign up now ✍️
ce.mayo.edu/neurology-an...
https://ce.mayo.edu/neurology-and-…
February 3, 2025 at 12:25 PM
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️
Please sign up now ✍️
ce.mayo.edu/neurology-an...
Please sign up now ✍️
ce.mayo.edu/neurology-an...
Our new CASPR2 paper is out in Annals Neurology 🤩
Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰
These are NOT immunotherapy responsive. 👩🏾⚕️💊
We also report other nuggets in this thread 🧵 ⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰
These are NOT immunotherapy responsive. 👩🏾⚕️💊
We also report other nuggets in this thread 🧵 ⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Immunotherapy‐Resistant Neuropathic Pain and Fatigue Predict Quality‐of‐Life in Contactin‐Associated Protein‐Like 2 Antibody Disease
The long-term clinical outcomes and associated prognostic factors in contactin-associated protein-like 2 (CASPR2)-antibody diseases are unknown. A total of 75 participants with CASPR2 antibodies were...
onlinelibrary.wiley.com
January 19, 2025 at 2:00 PM
Our new CASPR2 paper is out in Annals Neurology 🤩
Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰
These are NOT immunotherapy responsive. 👩🏾⚕️💊
We also report other nuggets in this thread 🧵 ⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰
These are NOT immunotherapy responsive. 👩🏾⚕️💊
We also report other nuggets in this thread 🧵 ⬇️
onlinelibrary.wiley.com/doi/10.1002/...
Very pleased to see this online @NeuroCellPress
With colleagues at @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic Rochester, we summarise state of the art (and some history 😃) in autoimmune neurology…..ENJOY!!
dlvr.it/THL45K
With colleagues at @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic Rochester, we summarise state of the art (and some history 😃) in autoimmune neurology…..ENJOY!!
dlvr.it/THL45K
Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets
This article by Segal et al provides a comprehensive overview of immunopathogenic
mechanisms of autoimmune neurological disorders, focusing on the interplay between
humoral and cellular immunity, rece...
dlvr.it
January 14, 2025 at 3:00 AM
Very pleased to see this online @NeuroCellPress
With colleagues at @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic Rochester, we summarise state of the art (and some history 😃) in autoimmune neurology…..ENJOY!!
dlvr.it/THL45K
With colleagues at @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic Rochester, we summarise state of the art (and some history 😃) in autoimmune neurology…..ENJOY!!
dlvr.it/THL45K