Kostas
@maybeitsyaptaz.bsky.social
PhD Student in the Varelas Lab l Boston University Med l Lung capillary injury and regeneration l 🇬🇷 in 🇺🇸
Reposted by Kostas
Our latest study is out! We investigated the effects of inducing goblet airway epithelial cells in the lung arising from YAP/TAZ inhibition, finding distinct inflammatory networks with implications for disease. Congrats to team and first author Carina!
Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses - PubMed
The increased presence of goblet epithelial cells in conducting airways of the respiratory system is common in pulmonary disorders and is often accompanied by disrupted immune and alveolar responses. ...
pubmed.ncbi.nlm.nih.gov
September 11, 2025 at 2:58 PM
Our latest study is out! We investigated the effects of inducing goblet airway epithelial cells in the lung arising from YAP/TAZ inhibition, finding distinct inflammatory networks with implications for disease. Congrats to team and first author Carina!
🚴♂️ Excited to be riding in Escape to the Cape (Sept 26–28) to support the Alpha-1 Foundation & the American Lung Association! 🌊
Every mile helps raise awareness + funds for Alpha-1.
👉 Donate here: secure.alpha1.org/site/TR/Endu...
Every mile helps raise awareness + funds for Alpha-1.
👉 Donate here: secure.alpha1.org/site/TR/Endu...
A1F Riding for a Reason 2025: Mr. Konstantinos Kontodimas - Alpha-1 Foundation
secure.alpha1.org
September 16, 2025 at 3:07 AM
🚴♂️ Excited to be riding in Escape to the Cape (Sept 26–28) to support the Alpha-1 Foundation & the American Lung Association! 🌊
Every mile helps raise awareness + funds for Alpha-1.
👉 Donate here: secure.alpha1.org/site/TR/Endu...
Every mile helps raise awareness + funds for Alpha-1.
👉 Donate here: secure.alpha1.org/site/TR/Endu...
🚨 New paper alert!
Thrilled to share our latest work in AJRCMB:
“Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses”
👉 atsjournals.org/doi/abs/10.1165/rcmb.2025-0169OC
Thrilled to share our latest work in AJRCMB:
“Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses”
👉 atsjournals.org/doi/abs/10.1165/rcmb.2025-0169OC
September 16, 2025 at 2:53 AM
🚨 New paper alert!
Thrilled to share our latest work in AJRCMB:
“Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses”
👉 atsjournals.org/doi/abs/10.1165/rcmb.2025-0169OC
Thrilled to share our latest work in AJRCMB:
“Airway Goblet Metaplasia Resulting from YAP/TAZ Deletion Drives Pulmonary Inflammatory Responses”
👉 atsjournals.org/doi/abs/10.1165/rcmb.2025-0169OC
Reposted by Kostas
Despite the chaos and uncertainty, I am happy to share our latest publication. In this study, we mapped stromal changes in mammary carcinomas initiated by epithelial LATS1/2 kinase inhibition and demonstrated the effectiveness of TEAD inhibitors in this model.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche | EMBO reports
imageimageLATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary
epithelium drives the development of a pro-oncogenic stromal niche. Inhibitors of
YAP/TAZ-TEAD activity blo...
www.embopress.org
February 15, 2025 at 12:59 PM
Despite the chaos and uncertainty, I am happy to share our latest publication. In this study, we mapped stromal changes in mammary carcinomas initiated by epithelial LATS1/2 kinase inhibition and demonstrated the effectiveness of TEAD inhibitors in this model.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
