Max Haase
@maxhaase.bsky.social
Chief Yeast Officer. Evolution, genomes, chromatin, cell cycle, centromeres, and kinetochore are scientific passions. PostDoc with Andrea Musacchio @ MPI-Dortmund. 🇺🇸 -> 🇩🇪
New favorite worst graphical abstract just dropped.
July 7, 2025 at 12:17 PM
New favorite worst graphical abstract just dropped.
The ants were pre-loaded with a tasty tuna snack. So I think they were just very happy and energized.
May 30, 2025 at 7:00 AM
The ants were pre-loaded with a tasty tuna snack. So I think they were just very happy and energized.
We have the means to defeat AI-abusing students:
May 7, 2025 at 2:15 PM
We have the means to defeat AI-abusing students:
"the moose on the table"
April 23, 2025 at 2:09 PM
"the moose on the table"
How does the picture connect to the tweet? I dunno, but I am confident in He's mind it makes a world of sense.
February 26, 2025 at 8:35 AM
How does the picture connect to the tweet? I dunno, but I am confident in He's mind it makes a world of sense.
The George L Mosse Humanities Building at UW Madison is a brutalist masterpiece.
Its a shame it is on deaths door.
onwisconsin.uwalumni.com/how-the-huma...
Its a shame it is on deaths door.
onwisconsin.uwalumni.com/how-the-huma...
February 25, 2025 at 9:22 AM
The George L Mosse Humanities Building at UW Madison is a brutalist masterpiece.
Its a shame it is on deaths door.
onwisconsin.uwalumni.com/how-the-huma...
Its a shame it is on deaths door.
onwisconsin.uwalumni.com/how-the-huma...
From outside the US it’s put in parentheses
February 11, 2025 at 5:31 AM
From outside the US it’s put in parentheses
But I can grab the original post from my quote post.
February 10, 2025 at 2:11 PM
But I can grab the original post from my quote post.
Another day, another NYT opinion piece on "voices from the right" – their continuing series to present far-right viewpoints in a normalized light (www.nytimes.com/2025/01/27/o...)
ironically, the last time the published "voices from the left" appears to be from 1984 (seriously)
ironically, the last time the published "voices from the left" appears to be from 1984 (seriously)
January 27, 2025 at 8:01 AM
Another day, another NYT opinion piece on "voices from the right" – their continuing series to present far-right viewpoints in a normalized light (www.nytimes.com/2025/01/27/o...)
ironically, the last time the published "voices from the left" appears to be from 1984 (seriously)
ironically, the last time the published "voices from the left" appears to be from 1984 (seriously)
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.
November 19, 2024 at 8:46 AM
Post a perfect album from the 90s that isn’t Nirvana, Pearl Jam, Soundgarden, or Alice in Chains.
I probably need to increase the number of times I use yeast 😌
September 24, 2023 at 7:31 PM
I probably need to increase the number of times I use yeast 😌
13/ By tracking individual cells we saw that histone levels do not change prior to release from HU and are at mitotic levels. Thus, histone synthesis completed while DNA remained unreplicated.
August 29, 2023 at 2:49 PM
13/ By tracking individual cells we saw that histone levels do not change prior to release from HU and are at mitotic levels. Thus, histone synthesis completed while DNA remained unreplicated.
12/ By flow cytometry we could see DNA replication proceed following release from HU, but histone levels were constant.
August 29, 2023 at 2:49 PM
12/ By flow cytometry we could see DNA replication proceed following release from HU, but histone levels were constant.
9/ At this point I wanted to look at histone dynamics in H. uvarum itself, so we inserted a tagged H2A marker to track histone levels during the cell cycle using time-lapse imaging. Thanks to Jürgen Heinisch for kindly providing all transformation reagents and protocols.
August 29, 2023 at 2:48 PM
9/ At this point I wanted to look at histone dynamics in H. uvarum itself, so we inserted a tagged H2A marker to track histone levels during the cell cycle using time-lapse imaging. Thanks to Jürgen Heinisch for kindly providing all transformation reagents and protocols.
8/ H. uvarum Mcm1 is conserved and behaves exactly like an ancestral Mcm1/Arg80 protein (see: 10.1126/science.1240810)!
August 29, 2023 at 2:47 PM
8/ H. uvarum Mcm1 is conserved and behaves exactly like an ancestral Mcm1/Arg80 protein (see: 10.1126/science.1240810)!
6/ And the Mcm1 sites are responsible for the toxicity of Hanseniaspora histone promoters in S. cerevisiae!
August 29, 2023 at 2:47 PM
6/ And the Mcm1 sites are responsible for the toxicity of Hanseniaspora histone promoters in S. cerevisiae!
5/ We then looked at the cis elements in histones promoters across the yeast phylogeny – the Hanseniaspora FEL spp. rewired their cis-regulation from the ancestral Spt10-mode to a Mcm1-mode.
August 29, 2023 at 2:47 PM
5/ We then looked at the cis elements in histones promoters across the yeast phylogeny – the Hanseniaspora FEL spp. rewired their cis-regulation from the ancestral Spt10-mode to a Mcm1-mode.
4/ We found that the H. uvarum H3-H4 dimer works just fine, while its H2A-H2B dimer is not compatible in S. cerevisiae. Moreover, the promoters of Hanseniaspora core histones were super toxic in S. cerevisiae.
August 29, 2023 at 2:47 PM
4/ We found that the H. uvarum H3-H4 dimer works just fine, while its H2A-H2B dimer is not compatible in S. cerevisiae. Moreover, the promoters of Hanseniaspora core histones were super toxic in S. cerevisiae.
3/ We used our histone plasmid shuffling method (see: academic.oup.com/g3journal/ar...) to test if the H. uvarum histones (and their promoters) function in S. cerevisiae.
August 29, 2023 at 2:46 PM
3/ We used our histone plasmid shuffling method (see: academic.oup.com/g3journal/ar...) to test if the H. uvarum histones (and their promoters) function in S. cerevisiae.
2/ First, we found that one lineage of Hanseniaspora (the fast evolving lineage, FEL) lost one set of each H2A-H2B and H3-H4 gene clusters.
August 29, 2023 at 2:46 PM
2/ First, we found that one lineage of Hanseniaspora (the fast evolving lineage, FEL) lost one set of each H2A-H2B and H3-H4 gene clusters.