MattWolf-PhD
@mattwolf-phd.bsky.social
Immune modulatory biomaterials for treating cancer and cancer patients.
Biomaterials Scientist, Tissue Engineer, & Cancer Immunologist for the low, low price of a Biomedical Engineer. Interesting views and opinions are my own.
Biomaterials Scientist, Tissue Engineer, & Cancer Immunologist for the low, low price of a Biomedical Engineer. Interesting views and opinions are my own.
Congratulations to all authors and Dr. Buckenmeyer for our paper in Cancer Research @aacrjournals.bsky.social, "A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity." His image made Cover Art! aacrjournals.org/cancerres/ar...
July 9, 2025 at 5:00 PM
Congratulations to all authors and Dr. Buckenmeyer for our paper in Cancer Research @aacrjournals.bsky.social, "A 3D Self-Assembly Platform Integrating Decellularized Matrix Recapitulates In Vivo Tumor Phenotypes and Heterogeneity." His image made Cover Art! aacrjournals.org/cancerres/ar...
I'm pleased to announce that my lab will have a Postdoc opening this Fall in Biomaterials and Immune Engineering, with projects in Cancer Immunotherapy, Surgery, and 3D in vitro models. The lab is located at NCI Frederick, MD and we'll interview on a rolling basis starting as early as August.
July 9, 2025 at 4:38 PM
I'm pleased to announce that my lab will have a Postdoc opening this Fall in Biomaterials and Immune Engineering, with projects in Cancer Immunotherapy, Surgery, and 3D in vitro models. The lab is located at NCI Frederick, MD and we'll interview on a rolling basis starting as early as August.
And checkout our collaborators in the Duncan lab via the NCI-UMD partnership program and former PhD Dr. Devorah Cahn while you're at it:
November 22, 2024 at 11:33 AM
And checkout our collaborators in the Duncan lab via the NCI-UMD partnership program and former PhD Dr. Devorah Cahn while you're at it:
And 2 posters on 3D modeling the tumor stroma:
November 22, 2024 at 11:24 AM
And 2 posters on 3D modeling the tumor stroma:
We have 3 talks on Thursday and Friday on #immunoengineering
November 22, 2024 at 11:15 AM
We have 3 talks on Thursday and Friday on #immunoengineering
Thanks to @gakaur and @HowardU Chemistry for inviting me to discuss #biomaterials in #CancerImmunotherapy at their department seminar series. They were great hosts and it was a pleasure chatting with the students about #immunoengineering.
November 22, 2024 at 11:07 AM
Thanks to @gakaur and @HowardU Chemistry for inviting me to discuss #biomaterials in #CancerImmunotherapy at their department seminar series. They were great hosts and it was a pleasure chatting with the students about #immunoengineering.
Awesome talk by Sanjay Pal at the TERMIS world congress in Seattle!
He presented his work developing a ECM scaffold assisted therapeutic cancer vaccine. Come chat with him about it if you are around #TERMIS2024 @TERMIS
He presented his work developing a ECM scaffold assisted therapeutic cancer vaccine. Come chat with him about it if you are around #TERMIS2024 @TERMIS
November 22, 2024 at 11:15 AM
Awesome talk by Sanjay Pal at the TERMIS world congress in Seattle!
He presented his work developing a ECM scaffold assisted therapeutic cancer vaccine. Come chat with him about it if you are around #TERMIS2024 @TERMIS
He presented his work developing a ECM scaffold assisted therapeutic cancer vaccine. Come chat with him about it if you are around #TERMIS2024 @TERMIS
A really important discovery was that MatriSpheres matched the transcriptome of in vivo tumors via scRNAseq. Scissor analysis showed high similarity to the SIS MatriSpheres, with a smaller subset showing similarity to cells alone. Tumors are heterogeneous after all.
November 22, 2024 at 11:59 AM
A really important discovery was that MatriSpheres matched the transcriptome of in vivo tumors via scRNAseq. Scissor analysis showed high similarity to the SIS MatriSpheres, with a smaller subset showing similarity to cells alone. Tumors are heterogeneous after all.
An unexpected finding was that this assembly is completely cell-dependent. These are not gels! (like when you embed cells in Matrigel for organoids). Rather it’s localized cell mediated ECM assembly. Rheologically, nothing happens without cells.
November 22, 2024 at 11:50 AM
An unexpected finding was that this assembly is completely cell-dependent. These are not gels! (like when you embed cells in Matrigel for organoids). Rather it’s localized cell mediated ECM assembly. Rheologically, nothing happens without cells.
We discovered that we can co-assemble cancer cells and ECM into 3D structures in high-throughput methods that are as easy as spheroids! We process into ECM hydrogel precursors + cancer cells in the right conditions and MatriSpheres emerge with collagen rich stroma
November 22, 2024 at 11:42 AM
We discovered that we can co-assemble cancer cells and ECM into 3D structures in high-throughput methods that are as easy as spheroids! We process into ECM hydrogel precursors + cancer cells in the right conditions and MatriSpheres emerge with collagen rich stroma
ECM is complex to say the least and we wanted a flexible method to capture that complexity or study individual ECM molecules. Decellularized intestine (SIS) maintains tissue specific ECM composition (via proteomics) and is more similar to tumor ECM than other biomaterials
November 22, 2024 at 11:33 AM
ECM is complex to say the least and we wanted a flexible method to capture that complexity or study individual ECM molecules. Decellularized intestine (SIS) maintains tissue specific ECM composition (via proteomics) and is more similar to tumor ECM than other biomaterials
Our pre-print “Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly” is now online! Thanks to authors Michael Buckenmeyer & Elizabeth Brooks and @NCIResearchCtr for support. https://www.biorxiv.org/content/10.1101/2024.03.19.585805v1
November 22, 2024 at 11:15 AM
Our pre-print “Engineering Tumor Stroma Morphogenesis Using Dynamic Cell-Matrix Spheroid Assembly” is now online! Thanks to authors Michael Buckenmeyer & Elizabeth Brooks and @NCIResearchCtr for support. https://www.biorxiv.org/content/10.1101/2024.03.19.585805v1
The paint is dry and it looks really good! Iris is a talented artist-scientist.
November 22, 2024 at 11:24 AM
The paint is dry and it looks really good! Iris is a talented artist-scientist.
Eclipse Activity: painting the inside of an obsolete live-cell imaging box to block out light for our more sensitive microscopy. It seemed like the right time for such a project.
November 22, 2024 at 11:15 AM
Eclipse Activity: painting the inside of an obsolete live-cell imaging box to block out light for our more sensitive microscopy. It seemed like the right time for such a project.
The anti-tumor effect was even stronger in older mice. Not only did the ECM scaffold assisted vaccine cure the tumor (EG.7-OVA) to improve survival, it prevented the tumor from coming back when rechallenged (memory), and partially protected against similar tumors (EL-4).
November 22, 2024 at 12:07 PM
The anti-tumor effect was even stronger in older mice. Not only did the ECM scaffold assisted vaccine cure the tumor (EG.7-OVA) to improve survival, it prevented the tumor from coming back when rechallenged (memory), and partially protected against similar tumors (EL-4).
So why do we care? ECM scaffolds are helpful in cancer care to reconstruct tissues after surgery. They induce alternative inflammation (pSTAT6, IL4), which is good for healing, but nobody knew if you could get cytotoxic T cell immunity from that.
November 22, 2024 at 11:59 AM
So why do we care? ECM scaffolds are helpful in cancer care to reconstruct tissues after surgery. They induce alternative inflammation (pSTAT6, IL4), which is good for healing, but nobody knew if you could get cytotoxic T cell immunity from that.
We screened several immune adjuvants and found that extracellular matrix (ECM) scaffold delivery (decellularized SIS ) enhanced vaccine efficacy with the STING pathway agonist CDA + protein antigen (OVA). ECM scaffold-assisted vaccines caused mouse tumors to shrink away.
November 22, 2024 at 11:50 AM
We screened several immune adjuvants and found that extracellular matrix (ECM) scaffold delivery (decellularized SIS ) enhanced vaccine efficacy with the STING pathway agonist CDA + protein antigen (OVA). ECM scaffold-assisted vaccines caused mouse tumors to shrink away.
Stop by on Thursday at 1:15pm to see back-to-back talks by postbac @rohanchaudhar1 and postdoc Sanjay Pal about the immunomodulatory properties of decellularized ECM scaffolds delivered with cancer vaccine adjuvants. Non-classical biomaterial immune response meets vaccines...
November 22, 2024 at 11:59 AM
Stop by on Thursday at 1:15pm to see back-to-back talks by postbac @rohanchaudhar1 and postdoc Sanjay Pal about the immunomodulatory properties of decellularized ECM scaffolds delivered with cancer vaccine adjuvants. Non-classical biomaterial immune response meets vaccines...
Check out rapid fire talks today (Weds) by postdoc fellow Mike Buckenmeyer and postbac Madison Taylor about "tumor tissue engineering" starting at 3pm. They are building 3D cell-ECM constructs that mimic the tumor microenvironment and look very cool.
November 22, 2024 at 11:50 AM
Check out rapid fire talks today (Weds) by postdoc fellow Mike Buckenmeyer and postbac Madison Taylor about "tumor tissue engineering" starting at 3pm. They are building 3D cell-ECM constructs that mimic the tumor microenvironment and look very cool.
To upcoming PhD/BS grads, I am hiring postdocs and postbacs for The Cancer Biomaterials Engineering Section @theNCI. If interested in immunomodulatory #biomaterials in #cancer, read below for details. @NIH @SFBiomaterials #immunotherapy #immunoengineering
November 22, 2024 at 11:50 AM
To upcoming PhD/BS grads, I am hiring postdocs and postbacs for The Cancer Biomaterials Engineering Section @theNCI. If interested in immunomodulatory #biomaterials in #cancer, read below for details. @NIH @SFBiomaterials #immunotherapy #immunoengineering
First week of being a PI @theNCI is officially in the books!! Gotta say, it’s surprisingly satisfying getting those first few orders delivered.
November 22, 2024 at 12:07 PM
First week of being a PI @theNCI is officially in the books!! Gotta say, it’s surprisingly satisfying getting those first few orders delivered.
Really excited to announce that I’ve accepted an LOI for a tenure track investigator position at the @NIH National Cancer Institute in Frederick, MD. I’m starting a biomaterials immunoengineering lab as a Stadtman Investigator in the LCIM, starting early fall. (1/3)
November 22, 2024 at 12:07 PM
Really excited to announce that I’ve accepted an LOI for a tenure track investigator position at the @NIH National Cancer Institute in Frederick, MD. I’m starting a biomaterials immunoengineering lab as a Stadtman Investigator in the LCIM, starting early fall. (1/3)