Maria Antonietta Tosches
@matosches.bsky.social
Associate Professor @ Columbia University. Brain evolution, plasticity and regeneration. www.tosches-lab.com
Interestingly, Cajal-Retzius cells are VERY similar at the transcriptomic level to another ancestral cell type, the external tufted cell in the olfactory bulb. This suggests that Cajal-Retzius cells may have evolved in early vertebrates from cells involved in olfactory processing. 🧵 6/7
August 25, 2025 at 7:43 PM
Interestingly, Cajal-Retzius cells are VERY similar at the transcriptomic level to another ancestral cell type, the external tufted cell in the olfactory bulb. This suggests that Cajal-Retzius cells may have evolved in early vertebrates from cells involved in olfactory processing. 🧵 6/7
… Eli Gumnit started digging into our new salamander developmental scRNAseq dataset and, long story short, found that 80 cells (out of 127,788 cells) had an unmistakable Cajal-Retzius cell transcriptomic profile! 🧵 4/7
August 25, 2025 at 7:43 PM
… Eli Gumnit started digging into our new salamander developmental scRNAseq dataset and, long story short, found that 80 cells (out of 127,788 cells) had an unmistakable Cajal-Retzius cell transcriptomic profile! 🧵 4/7
More than 100 years ago, Santiago Ramon y Cajal and Gustaf Retzius independently described intriguing neurons on the surface of the developing cortex. Decades later, Cajal-Retzius cells were found to release Reelin, a signaling molecule critical for the correct development of cortical layering 🧵 2/7
August 25, 2025 at 7:43 PM
More than 100 years ago, Santiago Ramon y Cajal and Gustaf Retzius independently described intriguing neurons on the surface of the developing cortex. Decades later, Cajal-Retzius cells were found to release Reelin, a signaling molecule critical for the correct development of cortical layering 🧵 2/7