The Matile Group
@matilegroup.bsky.social
Supramolecular Systems (th)at Work
www.unige.ch/sciences/chiorg/matile/
www.unige.ch/sciences/chiorg/matile/
In our new review in Helv. Chim. Acta, we summarize the first decade of CPDs – cell-penetrating poly(disulfide)s - comprehensively. It was gratifying to see how useful their thiol-mediated uptake has become in practice, also in living animals.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 17, 2025 at 6:45 AM
In our new review in Helv. Chim. Acta, we summarize the first decade of CPDs – cell-penetrating poly(disulfide)s - comprehensively. It was gratifying to see how useful their thiol-mediated uptake has become in practice, also in living animals.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Our new paper in Angew. Chem. could make thiol-mediated uptake more generally useful for the community, at last: Grafting CPDs to SOIs rather than the original grafting-from provides the fast bioconjugation needed.
Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...
Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...
November 6, 2025 at 8:27 PM
Our new paper in Angew. Chem. could make thiol-mediated uptake more generally useful for the community, at last: Grafting CPDs to SOIs rather than the original grafting-from provides the fast bioconjugation needed.
Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...
Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to Dr. Felix Bayard for a successful PhD defense, covering impressive synthetic efforts to reduce the phototoxicity of mechanosensitive flipper probes: Very best wishes for the future!
A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.
A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.
October 31, 2025 at 7:51 PM
Congratulations to Dr. Felix Bayard for a successful PhD defense, covering impressive synthetic efforts to reduce the phototoxicity of mechanosensitive flipper probes: Very best wishes for the future!
A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.
A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.
Look at these shiny flippers, so many:
pubs.rsc.org/en/journals/...
pubs.rsc.org/en/journals/...
October 16, 2025 at 5:48 AM
Look at these shiny flippers, so many:
pubs.rsc.org/en/journals/...
pubs.rsc.org/en/journals/...
In our new paper in Chem. Sci., we show that the replacement of one oxygen by one sulfur atom in phospholipids affords phosphorothioate liposomes that penetrate cells by thiol-mediated uptake in intact form and with contributions neither from fusion nor from endocytosis.
September 30, 2025 at 11:43 AM
In our new paper in Chem. Sci., we show that the replacement of one oxygen by one sulfur atom in phospholipids affords phosphorothioate liposomes that penetrate cells by thiol-mediated uptake in intact form and with contributions neither from fusion nor from endocytosis.
Congratulations for an intriguing PhD defence and very best wishes to Dr. Michael Cognet for a great future.
A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.
A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.
September 27, 2025 at 7:16 AM
Congratulations for an intriguing PhD defence and very best wishes to Dr. Michael Cognet for a great future.
A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.
A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.
Our new paper in Angew. Chem. introduces an enabling method to make catalysis with externally applied electric fields compatible with organic synthesis.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
September 23, 2025 at 11:32 AM
Our new paper in Angew. Chem. introduces an enabling method to make catalysis with externally applied electric fields compatible with organic synthesis.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
For a great start into the new academic year, we climbed up to the largest glacier in the Alps, a UNESCO World Heritage Site.
September 16, 2025 at 11:22 AM
For a great start into the new academic year, we climbed up to the largest glacier in the Alps, a UNESCO World Heritage Site.
This invited commentary in Angew. Chem. highlights the importance of translational supramolecular chemistry, and the power of the big yellow sulfur atom in this context, despite its diabolic reputation.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
September 8, 2025 at 9:29 AM
This invited commentary in Angew. Chem. highlights the importance of translational supramolecular chemistry, and the power of the big yellow sulfur atom in this context, despite its diabolic reputation.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social and @oliverthornseshold.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
August 29, 2025 at 6:56 AM
Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social and @oliverthornseshold.bsky.social.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
552 flippers and a few crabs, what a cover, please enjoy
Thank you, JACS Au: pubs.acs.org/doi/10.1021/...
Thank you, JACS Au: pubs.acs.org/doi/10.1021/...
August 26, 2025 at 7:26 AM
552 flippers and a few crabs, what a cover, please enjoy
Thank you, JACS Au: pubs.acs.org/doi/10.1021/...
Thank you, JACS Au: pubs.acs.org/doi/10.1021/...
Thank you so much for reading: Our new paper on photocatalytic microenvironment proteomics of thiol-mediated uptake still hangs on in the top 20 of JACS Au. It aims to give a better understanding of a process that might be more important than we all expected.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
August 18, 2025 at 5:54 AM
Thank you so much for reading: Our new paper on photocatalytic microenvironment proteomics of thiol-mediated uptake still hangs on in the top 20 of JACS Au. It aims to give a better understanding of a process that might be more important than we all expected.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
In our new paper in JACS Au, with the Sagara group from the Institute of Science Tokyo, we introduce flippers than respond to stretching rather than compression and applicability to the materials rather than the life sciences (GOA).
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
August 6, 2025 at 6:10 AM
In our new paper in JACS Au, with the Sagara group from the Institute of Science Tokyo, we introduce flippers than respond to stretching rather than compression and applicability to the materials rather than the life sciences (GOA).
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Photocatalytic microenvironment proteomics identifies proteins in thiol-mediated uptake by covalent labeling without disturbing exchange network dynamics. We hope our new paper will help the community to better understand, explore and use this enigmatic process.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
July 2, 2025 at 6:48 AM
Photocatalytic microenvironment proteomics identifies proteins in thiol-mediated uptake by covalent labeling without disturbing exchange network dynamics. We hope our new paper will help the community to better understand, explore and use this enigmatic process.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Violating the EDB rules, access to intrinsically disfavored products increases with increasing electric fields applied to electromicrofluidic reactors with carbon nanotubes (besides conversion going from 0 to 100%).
Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC
Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC
June 2, 2025 at 2:07 PM
Violating the EDB rules, access to intrinsically disfavored products increases with increasing electric fields applied to electromicrofluidic reactors with carbon nanotubes (besides conversion going from 0 to 100%).
Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC
Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC
Congratulations to Filipe Coelho for a great PhD defense, on uptake exchange partners, integrins, PDIs, cell motility, selenenylsulfides, and more. Many thanks for all and very best wishes for a bright future.
Special thanks also to jury members, specially C. Hackenberger, who came from far.
Special thanks also to jury members, specially C. Hackenberger, who came from far.
January 28, 2025 at 5:31 PM
Congratulations to Filipe Coelho for a great PhD defense, on uptake exchange partners, integrins, PDIs, cell motility, selenenylsulfides, and more. Many thanks for all and very best wishes for a bright future.
Special thanks also to jury members, specially C. Hackenberger, who came from far.
Special thanks also to jury members, specially C. Hackenberger, who came from far.
An update on dynamic covalent cascade exchange chemistry, thiol-mediated uptake and the CH-ERC AdG TIMEUP, now new in Chimia, the POA Journal of the Swiss Chemical Society.
www.chimia.ch/chimia/artic...
www.chimia.ch/chimia/artic...
November 25, 2024 at 7:52 AM
An update on dynamic covalent cascade exchange chemistry, thiol-mediated uptake and the CH-ERC AdG TIMEUP, now new in Chimia, the POA Journal of the Swiss Chemical Society.
www.chimia.ch/chimia/artic...
www.chimia.ch/chimia/artic...
Congratulations, Angie - Dr. Gutiérrez-López
for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis”
A big thank you for all and best wishes for the future!
Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour
for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis”
A big thank you for all and best wishes for the future!
Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour
November 22, 2024 at 6:43 AM
Congratulations, Angie - Dr. Gutiérrez-López
for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis”
A big thank you for all and best wishes for the future!
Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour
for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis”
A big thank you for all and best wishes for the future!
Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour
Hello #ChemSky, we are a research group in Geneva, Switzerland, interested in translating principles from supramolecular chemistry to address significant challenges at the interface of organic chemistry, chemical biology and materials.
November 19, 2024 at 7:43 PM
Hello #ChemSky, we are a research group in Geneva, Switzerland, interested in translating principles from supramolecular chemistry to address significant challenges at the interface of organic chemistry, chemical biology and materials.