Mathéa Geraud
@mathea-geraud.bsky.social
Academic clinical lecturer | Research at CRCT, Team SIGNATHER.
Interested in DNA damage & repair | Transcription | Cancer | Neurodegeneration
Interested in DNA damage & repair | Transcription | Cancer | Neurodegeneration
Sharing here our last published work on the role of mutated TDP1 in the accumulation of transcriptional DSBs. In CellReports, from Olivier Sordet's lab and Giovanni Capranico's lab. Many thanks to all co-authors!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
Geraud et al. generate human SCAN1 cells by CRISPR-Cas9 to study SCAN1 disease. SCAN1
cells accumulate transcriptional DSBs specifically in G1 phase due to enhanced DSB
formation and defective repair....
www.cell.com
November 15, 2024 at 8:41 PM
Sharing here our last published work on the role of mutated TDP1 in the accumulation of transcriptional DSBs. In CellReports, from Olivier Sordet's lab and Giovanni Capranico's lab. Many thanks to all co-authors!
www.cell.com/cell-reports...
www.cell.com/cell-reports...