@mateibolborea.bsky.social
#Neuroscientist #BabyMD interested in the hypothalamus @inserm.fr and @uni-of-warwick.bsky.social, @bsneuroendo.bsky.social board trustee, also Capoeirista, Beekeeper, Letters Craftsman, Biker 🏴☠️🇫🇷🇬🇧🇷🇴🇪🇺
Reposted
#Sleep alteration is a prominent feature of both #ageing and #neurodegeneration; but are they mechanistically distinct? Our latest review explores converging mechanisms and their translational relevance in #Alzheimer, #Parkinson, #Huntington, #ALS and #FTD and ageing.
doi.org/10.1111/jne....
doi.org/10.1111/jne....
<em>Journal of Neuroendocrinology</em> | BSN Journal | Wiley Online Library
Sleep and circadian rest-activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegen...
doi.org
September 8, 2025 at 10:11 AM
#Sleep alteration is a prominent feature of both #ageing and #neurodegeneration; but are they mechanistically distinct? Our latest review explores converging mechanisms and their translational relevance in #Alzheimer, #Parkinson, #Huntington, #ALS and #FTD and ageing.
doi.org/10.1111/jne....
doi.org/10.1111/jne....
Reposted
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
JCI -
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
doi.org
November 7, 2025 at 11:14 AM
Could subtle changes in #sleep patterns indicate #ALS long before symptoms manifest? In presymptomatic carriers and early patients, #EEG revealed early & brain-wide loss of microarchitectural oscillations, linked to memory and cognitive decline (@jci.org).
doi.org/10.1172/JCI1...
doi.org/10.1172/JCI1...
Our work on #sleep and #ALS is out now. JCI - Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis www.jci.org/articles/vie...
JCI -
Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis
www.jci.org
November 7, 2025 at 1:17 PM
Our work on #sleep and #ALS is out now. JCI - Early brain-wide disruption of sleep microarchitecture in Amyotrophic Lateral Sclerosis www.jci.org/articles/vie...
Sleep in neurodegenerative diseases: A focus on melatonin, melanin‐concentrating hormone and orexin - Guillot - Journal of Neuroendocrinology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
<em>Journal of Neuroendocrinology</em> | BSN Journal | Wiley Online Library
Sleep and circadian rest-activity rhythm alterations are recognised as inherent clinical features of various neurodegenerative diseases. Traditionally viewed as secondary manifestations of neurodegen...
onlinelibrary.wiley.com
September 7, 2025 at 7:17 PM
Sleep in neurodegenerative diseases: A focus on melatonin, melanin‐concentrating hormone and orexin - Guillot - Journal of Neuroendocrinology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
The wonderful land of science www.embopress.org/doi/full/10....
A career in science requires a thick skin | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
June 30, 2025 at 4:34 AM
The wonderful land of science www.embopress.org/doi/full/10....
This is really cool and unexpected www.science.org/doi/10.1126/...
Improving mental health by training the suppression of unwanted thoughts
Training people to suppress fearful thoughts improved mental health, especially for those with anxiety and post-traumatic stress.
www.science.org
February 23, 2025 at 11:08 AM
This is really cool and unexpected www.science.org/doi/10.1126/...
Reposted
Dans la sclérose latérale amyotrophique, une étude française pointe la présence de troubles du sommeil précurseurs aux symptômes moteurs et respiratoires.
Maladie de Charcot : les troubles du sommeil précéderaient l’apparition des symptômes moteurs
Les troubles du sommeil précèdent l’apparition des atteintes motrices et respiratoires de la sclérose latérale amyotrophique (SLA) ou maladie de Charcot, mettent en évidence les travaux d’une équipe du Centre de recherche en biomédecine (Inserm, Université de Strasbourg), en collaboration avec le centre allemand d’étude des maladies neurodégénératives (DZNE) d’Ulm.
www.lequotidiendumedecin.fr
February 5, 2025 at 8:23 PM
Dans la sclérose latérale amyotrophique, une étude française pointe la présence de troubles du sommeil précurseurs aux symptômes moteurs et respiratoires.
Reposted
A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models
In amyotrophic lateral sclerosis, sleep defects occur in patients, risk gene carriers, and mouse models in which they are rescued preclinically by an orexin antagonist.
www.science.org
January 30, 2025 at 11:04 AM
A new collaborative paper is out... a surprising new non-conventional phenotype in ALS, and a way to treat it:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🚨 New research reveals that sleep disorders appear very early in ALS! 🧠💤
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models | Science Translational Medicine www.science.org/doi/10.1126/...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models | Science Translational Medicine www.science.org/doi/10.1126/...
January 31, 2025 at 1:29 PM
🚨 New research reveals that sleep disorders appear very early in ALS! 🧠💤
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models | Science Translational Medicine www.science.org/doi/10.1126/...
Early-onset sleep alterations found in patients with amyotrophic lateral sclerosis are ameliorated by orexin antagonist in mouse models | Science Translational Medicine www.science.org/doi/10.1126/...