Hey Mathieu, c‘est jamais fun mais on est déjà entrain de préparer la soumission pour un autre journal. Ça va marcher d’une manière ou d’une autre :)

I have also developed novel algorithms, using opencv, for the quantification of condensates properties in microscropy pictures. Check my github for more information! github.com/mas-gu/llps_...

I have created the video showcasing the PDIA6 condensate dynamics and function using Blender and the Molecular Nodes module! Visualizing science like never before. #Blender #MolecularNodes @bradyajohnston.bsky.social

Our results show PDIA6 condensates recruit key chaperones (BiP, ERdj3, Grp94) to enhance proinsulin folding & prevent misfolding, driven by Ca²⁺. This opens new perspectives for tackling protein misfolding diseases like diabetes! @natcellbio.nature.com

Merci Mathieu!

Thanks, glad you like it!

It’s fully adaptable to study other nucleotide-driven machines, dissecting functional cycles, regulation, and cofactor effects with unprecedented resolution. #MolecularMachine

Applied to the Hsp70 BiP NBD, in-cyclo NMR reveals all 11 microscopic kinetic rates of ATP binding, hydrolysis & product release — showing ADP·Pi release, not ATP hydrolysis, is the rate-limiting step controlling the cycle duration.