Condensed chromatin domain structure and cohesin-constrained mobility assure independent transcription regulation for each domain!
Also consistent with many previous studies.
(4/n)

We got a clue to my unsolved question from high school 🌱
“Chromatin loop organization insulates transcription”—a schematic I once scribbled in my textbook like this.
But ever since, I’ve wondered: How can neighboring loops avoid interacting?
(3/n)

All efforts by coauthors made this happen! :
@katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san, @lschermelleh.bsky.social ‬, Toyoda-san, Kurokawa-san.
And, as always, I deeply appreciate @kazu-maeshima.bsky.social 's supervision!
(2/n)

Thank you very much!
Hope you enjoy reading!

Thank you for your kind words.
It was great to meet you, and I enjoyed your talk!

Go to the link to see our preprint about linker histone H1!
www.biorxiv.org/content/10.1...

Huge thanks to Rosana @rcollepardo.bsky.social, Charlie, Jan @janhuemar.bsky.social, and Stephen! 🙌
Their simulations revealed in stunning detail how H1 and nucleosomes interact.
I was amazed—so consistent with our experiments! 🔬💻
(4/n)

Single molecule imaging revealed that H1 behaves like a liquid inside chromatin! 🫧
It's amazing to witness how H1 behaves in living cells 🔬✨
(3/n)